Tong Sebastian T, Gottlieb Michael, Ebna Mannan Imtiaz, Zheng Zihan, Sinha Manisha, Santangelo Michelle, Gatling Kristyn, Kean Efrat, Watts Phillip, Wang Ralph, Montoy Juan Carlos, Idris Ahamed, MacDonald Samuel, Huebinger Ryan, Hill Mandy, O'Laughlin Kelli N, Gentile Nicole L, Dorney Jocelyn, Malicki Caitlin, Elmore Joann G, Diaz Roldan Kate, Chan Gary, Lin Zhenqiu, Weinstein Robert A, Stephens Kari A
Department of Family Medicine, University of Washington, 4225 Roosevelt Way NE, Suite 308, Seattle, WA, 98105, United States.
Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, 600 S. Paulina St, Chicago, IL, 60612, United States.
Alcohol Alcohol. 2024 Nov 18;60(1). doi: 10.1093/alcalc/agae086.
Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals.
Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes.
Of 3529 individuals, 23.7% screened positive for binge drinking. At three months, prior self-reported binge drinking was associated with differences in physical function [estimate: 1.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: -0.86; 95% CI -1.57, -0.15), and physical health (estimate: 1.09; 95% CI 0.43, 1.75). At six months, no associations were found between binge drinking and outcomes.
Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three months, which were not sustained at six months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.
在新冠疫情期间，酒精消费以及过量饮酒带来的负面后果有所增加。我们评估了新冠病毒检测呈阳性的个体中暴饮酒精与长期功能结局之间的关联。
采用前瞻性、纵向、多中心队列研究设计，我们在感染后三个月和六个月使用患者报告结局测量信息系统（PROMIS）-29评分评估暴饮酒精与心理和身体功能结局之间的关联。符合条件的患者是那些出现新冠病毒样症状、新冠病毒检测呈阳性且完成了为期三个月调查的人。在感染时使用烟草、酒精、处方药和其他物质使用筛查工具来确定暴饮情况。使用广义估计方程模型，并对人口统计学特征、健康的社会决定因素、物质使用、合并症和新冠疫苗接种状况进行调整，以评估暴饮酒精与心理和身体功能结局之间的关联。
在3529名个体中，23.7%的人暴饮筛查呈阳性。在三个月时，之前自我报告的暴饮与身体功能差异[估计值：1.08；95%置信区间（CI）0.44，1.71]、疼痛干扰（估计值：-0.86；95%CI -1.57，-0.15）和身体健康（估计值：1.09；95%CI 0.43，1.75）有关。在六个月时，未发现暴饮与结局之间存在关联。
新冠病毒感染前的暴饮酒精与三个月时功能上具有统计学意义但临床意义不大的改善有关，而这种改善在六个月时并未持续。感染后和疫情后的应激源可能对功能结局的影响比暴饮酒精更大。暴饮的较高频率及其与功能结局的关联，特别是在新冠病毒感染者中，值得进一步研究。
