Jacobs Wura, DeLeon Angela, Bristow Alane, Quinn Patrick, Lederer Alyssa
Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, Indiana, United States of America.
Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
PLoS One. 2025 Jan 2;20(1):e0316349. doi: 10.1371/journal.pone.0316349. eCollection 2025.
College students are at higher risk for problematic substance use and disordered eating. Few studies have examined the comorbid risks associated with OCD despite the increased prevalence of OCD among young adults. This study examined substance use and disordered eating risk associated with OCD conditions among college students and how this association may vary by sex/gender.
Data were from 92,757 undergraduate students aged 18-24 enrolled in 216 colleges between Fall 2021 and Fall 2022, from the American College Health Association-National College Health Assessment III. Regression models were used to estimate alcohol, cannabis, tobacco, and disordered eating risk among those with OCD related conditions compared to those without conditions, overall and by sex/gender, while adjusting for covariates and school clustering.
Students with OCD conditions displayed a higher prevalence of substance use and disordered eating risks. In adjusted models, OCD conditions were associated with increased odds of moderate/high tobacco (aOR = 1.12, 95% CI 1.05, 1.21), cannabis (aOR = 1.11, 95% CI 1.04, 1.18), alcohol (aOR = 1.14, 95% CI 1.05, 1.24) and disordered eating risk (aOR = 2.28, 95% CI 2.13, 2.43). Analyses stratified by gender revealed cis-female students with OCD conditions were at increased risk for moderate/high risk alcohol (aOR = 1.18, 95% CI 1.08, 1.29), tobacco (aOR = 1.12, 95% CI 1.03, 1.22), cannabis (aOR = 1.13, 95% CI 1.06, 1.23) and disordered eating (aOR = 2.30, 9%% CI 2.14, 2.47). Among TGNC students, OCD conditions were associated with increased risk for moderate/high tobacco risk (aOR = 1.24, 95% CI 1.05, 1.48) and disordered eating (aOR = 2.14, 95% CI 1.85, 2.47). OCD conditions was only associated with disordered eating among male students (aOR = 2.34, 95% CI 1.93, 2.83).
Young adult college students with OCD conditions exhibit a higher prevalence of medium/high risk alcohol, tobacco, and cannabis use and disordered eating compared to their counterparts without such conditions, even after adjusting for stress, depression, and anxiety.
大学生存在物质使用问题和饮食失调的风险更高。尽管强迫症在年轻人中的患病率有所上升，但很少有研究探讨与强迫症相关的共病风险。本研究调查了大学生中与强迫症相关的物质使用和饮食失调风险，以及这种关联如何因性别而异。
数据来自2021年秋季至2022年秋季期间在216所大学就读的92757名18 - 24岁的本科生，数据来自美国大学健康协会 - 全国大学健康评估III。使用回归模型估计患有强迫症相关疾病的学生与未患该疾病的学生相比，总体以及按性别划分的酒精、大麻、烟草和饮食失调风险，同时对协变量和学校聚类进行调整。
患有强迫症的学生物质使用和饮食失调风险的患病率更高。在调整后的模型中，强迫症与中度/高度烟草使用（调整后比值比[aOR]=1.12，95%置信区间[CI] 1.05，1.21）增加的几率、大麻使用（aOR = 1.11，95% CI 1.04，1.18）、酒精使用（aOR = 1.14，95% CI 1.05，1.24）和饮食失调风险（aOR = 2.28，95% CI 2.13，2.43）相关。按性别分层分析显示，患有强迫症的顺性别女性学生中度/高度酒精使用风险（aOR = 1.18，95% CI 1.08，1.29）、烟草使用（aOR = 1.12，95% CI 1.03，1.22）、大麻使用（aOR = 1.13，95% CI 1.06，1.23）和饮食失调（aOR = 2.30，95% CI 2.14，2.47）的风险增加。在跨性别非顺性别（TGNC）学生中，强迫症与中度/高度烟草风险（aOR = 1.24，95% CI 1.05，1.48）和饮食失调（aOR = 2.14，95% CI 1.
