Paravatou-Petsota M, Muleris M, Prieur M, Dutrillaux B
Mutat Res. 1985 Mar;149(1):57-66. doi: 10.1016/0027-5107(85)90009-0.
A qualitative study is presented of chromosomal rearrangements induced by gamma-irradiation at 2 Gy and 3 Gy in peripheral blood lymphocytes of the chimpanzee Pan troglodytes. From a sample of 460 cells, karyotyped after R-banding, 1047 rearrangements were detected. Each type of rearrangement is analyzed according to the diagrammatic method previously developed. The non-random nature of the induction of the rearrangements is clear. The chimpanzee seems highly sensitive to the induction of dicentrics. This may be related to the existence, in its karyotype, of sensitive juxta-telomeric heterochromatin, much more frequently affected in the case of formation of dicentrics than of other types of rearrangements. Thus, the evaluation of radiation sensitivity of a given species based only on the yield of dicentrics may not have a general value for chromosomal mutagenesis.
本文呈现了一项定性研究，该研究针对黑猩猩（Pan troglodytes）外周血淋巴细胞在2 Gy和3 Gy伽马射线照射下诱导产生的染色体重排情况。在对460个经R带染色后进行核型分析的细胞样本进行检测后，共发现了1047种重排。根据先前开发的图示方法对每种重排类型进行了分析。重排诱导的非随机性很明显。黑猩猩似乎对双着丝粒的诱导高度敏感。这可能与其核型中存在敏感的近着丝粒异染色质有关，在形成双着丝粒的情况下，这种异染色质比其他类型的重排更容易受到影响。因此，仅基于双着丝粒的产量来评估给定物种的辐射敏感性，对于染色体诱变可能没有普遍价值。
