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经皮冠状动脉介入治疗后急性心肌梗死患者甘油三酯葡萄糖指数与全因死亡率的相关性

Correlation of triglyceride glucose index with all cause mortality in acute myocardial infarction patients following percutaneous coronary intervention.

作者信息

Yang Guang, Huang Zilun, Wang Shanjie, Yang Shuang

机构信息

Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, China.

The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.

出版信息

Sci Rep. 2025 Jan 2;15(1):243. doi: 10.1038/s41598-024-81432-9.

Abstract

The Triglyceride glucose (TyG) index is a dependable indicator of IR, with numerous studies underscoring its influence on Cardiovascular disease. Nevertheless, the connection between the TyG index and prognosis in AMI patients after PCI is still uncertain. This investigation aims to explore the link in individuals who have received PCI for AMI. Upon admission, data regarding the patients' age, sex, concurrent diseases, TyG index, and laboratory findings were meticulously documented. To discern the link between the TyG index and the 30-day and 12-month ACM, we employed a multivariate Cox proportional hazard regression model and K-M survival curve. The concordance evaluation was also enhanced by subgroup analysis. The investigation encompassed data from 1410 AMI patients who received PCI. The 30-day ACM rate was observed to be 15.1% (214/1410), while the rate at 12 months escalated to 26.0% (368/1410). Upon adjusting for potential confounders, multivariate analysis delineated a dramatic link between high TyG index and heightened mortality risk at both 30 days (HR 1.233, 95% CI 1.086-1.399) and 12 months (HR 1.127, 95% CI 0.963-1.318). According to K-M survival curve, patients presenting with higher TyG indexes demonstrated a noticeably higher probability of ACM within both the 30-day and 12-month. In AMI patients after PCI, the TyG index demonstrates a substantial link with ACM at 30-day and 12-month marks. This finding suggests the effectiveness of the TyG index in detecting AMI patients who are at a higher risk of mortality after undergoing PCI.

摘要

甘油三酯葡萄糖(TyG)指数是胰岛素抵抗的可靠指标,众多研究强调了其对心血管疾病的影响。然而,TyG指数与急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后的预后之间的关系仍不明确。本研究旨在探讨接受AMI PCI治疗的患者中两者的联系。入院时,详细记录了患者的年龄、性别、并发疾病、TyG指数和实验室检查结果。为了明确TyG指数与30天和12个月全因死亡(ACM)之间的联系,我们采用了多变量Cox比例风险回归模型和K-M生存曲线。亚组分析也加强了一致性评估。该研究纳入了1410例接受PCI治疗的AMI患者的数据。观察到30天的ACM发生率为15.1%(214/1410),而12个月时该发生率升至26.0%(368/1410)。在调整潜在混杂因素后,多变量分析表明高TyG指数与30天(风险比[HR] 1.233,95%置信区间[CI] 1.086 - 1.399)和12个月(HR 1.127,95% CI 0.963 - 1.318)时更高的死亡风险之间存在显著联系。根据K-M生存曲线,TyG指数较高的患者在30天和12个月内发生ACM的可能性明显更高。在接受PCI治疗的AMI患者中,TyG指数与30天和12个月时的ACM存在显著联系。这一发现表明TyG指数在检测接受PCI治疗后死亡风险较高的AMI患者方面具有有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bb7/11696181/7c7816d50a43/41598_2024_81432_Fig1_HTML.jpg

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