Thevenet F, Keshmiri S, Degouttes J, Livingstone J, Lu G, Adam J, Pittet P
Universite Claude Bernard Lyon 1, INL, UMR5270, CNRS, INSA Lyon, Ecole Centrale de Lyon, CPE Lyon, 69622, Villeurbanne, France.
Univ. Grenoble Alpes, INSERM, UA07 STROBE, 2280 rue de la piscine, 38400, Saint-Martin d'Hères, France.
Sci Rep. 2025 Jan 2;15(1):277. doi: 10.1038/s41598-024-80736-0.
Synchrotron microbeam radiotherapy (MRT), which has entered the clinical transfer phase, requires the development of appropriate quality assurance (QA) tools due to very high dose rates and spatial hyperfractionation. A microstrip plastic scintillating detector system with associated modules was proposed in the context of real-time MRT QA. A prototype of such a system with 105 scintillating microstrips was developed and tested under MRT conditions. The signal obtained from each microstrip when irradiated was reproducible, linear with the dose, and independent of both the dose rate and the beam energy. The detector prototype was capable of measuring an entire 52-microbeam field in real time and exhibited outstanding radiation hardness. It could withstand more than 100 kGy absorbed dose, which is at least ten times higher than the doses reported in the literature for plastic scintillators before deterioration. The potential of this detector system in MRT QA was demonstrated in this study.
同步加速器微束放射治疗(MRT)已进入临床转化阶段,由于其极高的剂量率和空间超分割特性,需要开发合适的质量保证(QA)工具。在实时MRT质量保证的背景下,提出了一种带有相关模块的微带塑料闪烁探测器系统。开发了一个具有105个闪烁微带的这种系统的原型,并在MRT条件下进行了测试。照射时从每个微带获得的信号是可重复的,与剂量呈线性关系,并且与剂量率和束能量均无关。探测器原型能够实时测量整个52微束场,并表现出出色的辐射硬度。它能够承受超过100 kGy的吸收剂量,这比文献中报道的塑料闪烁体在劣化前的剂量至少高十倍。本研究证明了该探测器系统在MRT质量保证中的潜力。