Kim Soyeon, Ko Hyunwoong, Myung Woojae, Yoon Joohyun, Kim Kiwon, Jung Sang-Hyuk, Shim Injeong, Cha Soojin, Kim Beomsu, Kang Jae Myeong, Park Woong-Yang, Natarajan Pradeep, Do Ron, Won Hong-Hee
Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
Nat Cardiovasc Res. 2025 Jan;4(1):15-25. doi: 10.1038/s44161-024-00581-2. Epub 2025 Jan 2.
Participation in leisure and social activities (LSA) is associated with better health outcomes and lower mortality. Previous observational studies demonstrated a relationship between engagement in LSA and both mental and physical health. Although several studies examined the association between LSA and health outcomes, including cardiovascular disease, their possible causal relationship has not been studied. In this study, we investigated the causal relationship between LSA and various health outcomes, including cardiovascular disease, using data from genome-wide association study summary statistics (sample size = 63,926-1,557,411) and a Mendelian randomization approach. Genetically predicted LSA were associated with a reduced risk of several health outcomes, including coronary artery disease and coronary atherosclerosis. Mediation analysis indicated that these effects were partly mediated by modifiable risk factors, such as body mass index, smoking and lipid levels. These findings highlight the importance of LSA in disease prevention and health promotion.
参与休闲和社交活动（LSA）与更好的健康结果及更低的死亡率相关。以往的观察性研究表明，参与LSA与身心健康之间存在关联。尽管有几项研究考察了LSA与包括心血管疾病在内的健康结果之间的关联，但其可能的因果关系尚未得到研究。在本研究中，我们使用全基因组关联研究汇总统计数据（样本量 = 63,926 - 1,557,411）和孟德尔随机化方法，研究了LSA与包括心血管疾病在内的各种健康结果之间的因果关系。基因预测的LSA与多种健康结果风险降低相关，包括冠状动脉疾病和冠状动脉粥样硬化。中介分析表明，这些影响部分由可改变的风险因素介导，如体重指数、吸烟和血脂水平。这些发现凸显了LSA在疾病预防和健康促进中的重要性。
