Kienbacher Calvin Lukas, Schörgenhofer Christian, Ruzicka Gerhard, Grafeneder Jürgen, Hufnagl Christine, Jilma Bernd, Schwameis Michael, Herkner Harald
Department of Emergency Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Sci Rep. 2025 Jan 2;15(1):123. doi: 10.1038/s41598-024-84070-3.
Allergic reactions and angioedema are important immunologic conditions in acute care settings. Prior data indicate an association between symptom severity and maximum lysis (ML) in thromboelastometry. We aimed to evaluate the dynamics of ML two hours after admission to the emergency department. We determined ML with thromboelastometry using extrinsic testing (EXTEM, ROTEM, Werfen GmbH, Munich, Germany) at the presentation of patients with immunologic reactions and approximately two hours thereafter (after the observation interval). The median test was used to compare the extent of ML between individuals who were still symptomatic after the observation interval and those who were asymptomatic. We prospectively enrolled 16 individuals (10 (63%) female, mean age 50 ± 14 years). Of these, 6 (38%) were still symptomatic after the observation interval. These patients at that time had significantly higher ML than those who were asymptomatic (14% (IQR 12-17) vs. 8% (IQR 4-10), p = 0.002). To conclude, in emergency department patients with immunologic reactions, symptoms after 2 h of observation may be associated with alterations in ML.
过敏反应和血管性水肿是急性护理环境中的重要免疫病症。先前的数据表明血栓弹力图中症状严重程度与最大溶解（ML）之间存在关联。我们旨在评估急诊科入院两小时后ML的动态变化。我们在免疫反应患者就诊时以及此后约两小时（观察期后）使用外部检测（EXTEM、ROTEM，德国慕尼黑Werfen GmbH公司）通过血栓弹力图测定ML。使用中位数检验比较观察期后仍有症状的个体与无症状个体之间的ML程度。我们前瞻性地招募了16名个体（10名（63%）女性，平均年龄50±14岁）。其中，6名（38%）在观察期后仍有症状。这些患者此时的ML显著高于无症状患者（14%（四分位间距12 - 17）对8%（四分位间距4 - 10），p = 0.002）。总之，在急诊科有免疫反应的患者中，观察2小时后的症状可能与ML的改变有关。
