Thoman E B, Davis D H, Raye J R, Philipps A F, Rowe J C, Denenberg V H
Neuropediatrics. 1985 Feb;16(1):13-8. doi: 10.1055/s-2008-1052537.
This study investigated the prolonged effects on state behavior of theophylline administered to infants for apnea of prematurity. There were three groups: Four premature infants who had received theophylline in the preterm period, five premature infants who had not received theophylline, and twenty-eight normal fullterm infants. The Theophylline infants had been off the drug for at least one month prior to the beginning of the study. Sleep-wake states were observed in the home for seven-hour periods when all infants were the same corrected ages: two, three, four and five weeks post-term. Data from the portion of the day that the infants were alone were analysed for this study. The state organization of the Theophylline group differed significantly from those of the other groups. They exhibited more non-alert waking activity, more alert, more drowse or transition, and less active sleep than did the Non-Theophylline and Fullterm infants. The state distributions of the latter two groups did not differ. On the basis of similarities between the results of this study and of a previous animal study, it was concluded that theophylline altered the normal development of state organization in premature infants. These effects persisted long after the drug had cleared the body.
本研究调查了给早产婴儿使用氨茶碱治疗早产呼吸暂停对其状态行为的长期影响。研究分为三组：四名在早产期间接受过氨茶碱治疗的早产婴儿、五名未接受过氨茶碱治疗的早产婴儿以及二十八名正常足月婴儿。氨茶碱组婴儿在研究开始前已停药至少一个月。当所有婴儿的矫正年龄相同时，即在足月后两周、三周、四周和五周时，在家中观察其七小时的睡眠 - 觉醒状态。本研究分析了婴儿独处时段的数据。氨茶碱组的状态组织与其他组有显著差异。与未使用氨茶碱组婴儿和足月婴儿相比，他们表现出更多的非警觉清醒活动、更多的警觉、更多的瞌睡或过渡状态，以及更少的主动睡眠。后两组的状态分布没有差异。基于本研究结果与先前一项动物研究结果的相似性，得出结论：氨茶碱改变了早产婴儿状态组织的正常发育。这些影响在药物从体内清除后仍持续很长时间。
