Nelson R M, Resnick M B, Holstrum W J, Eitzman D V
Dev Pharmacol Ther. 1980;1(5):274-80.
The methylated xanthines are known to have multiple metabolic effects. This study was performed to examine the development of premature infants treated with theophylline in the neonatal period for apnea. The theophylline-treated infants had lower Apgar scores and gestational ages when compared to those who did not receive theophylline. There were no significant differences in the developmental indices, and both groups had similar incidences of severe neurologic sequelae and retrolental fibroplasia. Similarly, there were no differences in the somatic growth. The data suggest that theophylline does not adversely affect development of premature infants when examined at 9--27 months of age.
已知甲基化黄嘌呤具有多种代谢作用。本研究旨在检查在新生儿期接受茶碱治疗以缓解呼吸暂停的早产儿的发育情况。与未接受茶碱治疗的婴儿相比，接受茶碱治疗的婴儿阿氏评分和胎龄较低。发育指标无显著差异，两组严重神经后遗症和晶状体后纤维增生的发生率相似。同样，身体生长方面也没有差异。数据表明，在9至27个月龄时检查，茶碱对早产儿的发育没有不利影响。
