Xuan Yanyan, He Fangfang, Liu Qing, Dai Dandan, Wu Dingting, Shi Yanmei, Yao Qi
Department of Hospital Infection, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Department of Hepatology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Sci Rep. 2025 Jan 2;15(1):10. doi: 10.1038/s41598-024-84649-w.
This study investigated the association between NAFLD and liver fibrosis and the ratio of gamma-glutamyl transferase to high-density lipoprotein cholesterol (GGT/HDL-C). In this cross-sectional study, we included 4764 subjects who participated in the National Health and Nutrition Examination Survey (NHANES) during 2017-2018. Adjusted multivariate logistic regression analysis was utilized to evaluate the relationships between GGT/HDL-C levels and NAFLD, fatty liver degree, and liver fibrosis. The non-linear link between NAFLD and the GGT/HDL-C ratio was examined using generalized additive models. There was a non-linear association between GGT/HDL-C and the risk of NAFLD, and all regression models demonstrated a strong relationship between GGT/HDL-C levels and the risk of liver fibrosis, the degree of hepatic steatosis, and the prevalence of NAFLD. Subgroup analyses revealed a significant correlation between the risk of NAFLD and the GGT/HDL-C ratio among Mexican Americans and young people in the 20-40 age range. The receiver operating characteristic (ROC) study showed that GGT/HDL-C was a more accurate predictor of NAFLD than GGT or HDL-C alone. In the U.S. population, an increased risk of NAFLD, the severity of hepatic steatosis, and the risk of liver fibrosis are independently correlated with an elevated GGT/HDL-C ratio.
本研究调查了非酒精性脂肪性肝病（NAFLD）与肝纤维化以及γ-谷氨酰转移酶与高密度脂蛋白胆固醇比值（GGT/HDL-C）之间的关联。在这项横断面研究中，我们纳入了2017 - 2018年期间参加美国国家健康与营养检查调查（NHANES）的4764名受试者。采用调整后的多变量逻辑回归分析来评估GGT/HDL-C水平与NAFLD、脂肪肝程度和肝纤维化之间的关系。使用广义相加模型检验NAFLD与GGT/HDL-C比值之间的非线性联系。GGT/HDL-C与NAFLD风险之间存在非线性关联，所有回归模型均显示GGT/HDL-C水平与肝纤维化风险、肝脂肪变性程度和NAFLD患病率之间存在密切关系。亚组分析显示，墨西哥裔美国人以及20 - 40岁年龄段的年轻人中，NAFLD风险与GGT/HDL-C比值之间存在显著相关性。受试者工作特征（ROC）研究表明，GGT/HDL-C比单独的GGT或HDL-C更能准确预测NAFLD。在美国人群中，NAFLD风险增加、肝脂肪变性严重程度以及肝纤维化风险与GGT/HDL-C比值升高独立相关。
