Kerber C W, Cromwell L D, Zanetti P H
Neurosurgery. 1985 Jan;16(1):13-7.
Using our modification of the vein patch technique, we created 16 aneurysms in the common carotid arteries of dogs. After a stabilizing and healing period, these aneurysms were treated using percutaneous catheter techniques. Coaxial microcatheters were placed into the aneurysms, and a mixture of isobutyl 2-cyanoacrylate and tantalum dust was infused through the microcatheter using real time fluoroscopic control. Fifteen of the 16 aneurysms were successfully occluded; 1 was a failure because of total occlusion of the carotid artery. One human facial artery aneurysm was similarly treated. The ease and technical details of the treatment are discussed. Although the results are encouraging, we believe that it would be prudent to broaden the animal experimentation rather than to begin human use. Because no experimental aneurysm models are yet physiological, our results must be applied with caution to human intracranial aneurysms.
我们采用改良的静脉补片技术，在犬的颈总动脉上制造了16个动脉瘤。经过一段稳定和愈合期后，使用经皮导管技术对这些动脉瘤进行治疗。将同轴微导管置入动脉瘤内，并在实时荧光透视控制下，通过微导管注入异丁基2-氰基丙烯酸酯和钽粉的混合物。16个动脉瘤中有15个成功闭塞；1个因颈动脉完全闭塞而治疗失败。对1例人类面动脉动脉瘤进行了类似治疗。讨论了治疗的简便性和技术细节。尽管结果令人鼓舞，但我们认为谨慎的做法是扩大动物实验范围，而不是开始用于人体。由于目前尚无实验性动脉瘤模型符合生理情况，因此我们的结果应用于人类颅内动脉瘤时必须谨慎。
