Siqueira M G, Vieira I A, Cilião E A, Guerra D M
Arq Neuropsiquiatr. 1980 Mar;38(1):24-32. doi: 10.1590/s0004-282x1980000100004.
Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.
对成年杂种犬进行了研究，以评估通过血管内注射组织粘合剂布西拉（异丁基 - 2 - 氰基丙烯酸酯）闭塞囊状动脉瘤的可能性。通过荧光镜定位的动脉内导管注射布西拉，闭塞了14个手术构建的颈动脉动脉瘤。注射前后即刻以及治疗后长达1个月进行的血管造影显示动脉瘤逐渐且持续闭塞。注射后1个月进行组织学检查的标本显示，有一个内皮化的纤维组织桥穿过动脉瘤颈部，这似乎表明所治疗结构已永久闭塞。治疗颅内动脉瘤的类似方法将取决于选择性颅内导管插入术领域的进展，该进展将允许对动脉瘤囊进行安全且准确的导管插入。
