Davis S L, Aminoff M J, Panitch H S
Neurology. 1985 Mar;35(3):359-65. doi: 10.1212/wnl.35.3.359.
Serial median nerve somatosensory evoked potentials (SEPs) were recorded in 12 patients with definite MS. On the initial tests, there was no clear association between the severity of clinical disease activity and SEP findings. The cervical response was most frequently affected and, when present, was often abnormal in configuration, suggesting absence or delay in the far field P14 component with preservation of cervical N11 and N13 components. Clinical motor and sensory findings in the corresponding limb frequently correlated with abnormalities of the cervical response. When new motor and sensory findings developed in the arms during the study, the SEP deteriorated in some patients but improved in others. Most SEP changes were not accompanied by clinical changes. Overall disability sometimes increased during the study despite improvements in the SEP.
对12例确诊为多发性硬化症（MS）的患者进行了系列正中神经体感诱发电位（SEP）记录。在初始测试中，临床疾病活动的严重程度与SEP结果之间没有明显关联。颈部反应最常受到影响，当存在时，其形态通常异常，提示远场P14成分缺失或延迟，而颈部N11和N13成分保留。相应肢体的临床运动和感觉表现常与颈部反应异常相关。在研究期间，当手臂出现新的运动和感觉表现时，一些患者的SEP恶化，而另一些患者则改善。大多数SEP变化并未伴有临床变化。尽管SEP有所改善，但在研究期间总体残疾有时仍会增加。
