Scaioli V, Milanese C, Salmaggi A, LaMantia L, Campi A, Eoli M, Panzica F
Divisioni di Neurofisiopatologia Clinica e Neurologia, Istituto Nazionale Neurologico C. Besta, IRCCS, Milano.
Ital J Neurol Sci. 1992 Mar;13(2):107-12. doi: 10.1007/BF02226957.
Visual (VEP) and brainstem auditory (BAEP) evoked potentials (EP) were recorded in 21 multiple sclerosis (MS) patients in acute relapse before and after steroid treatment. VEPs were abnormal in 14/21 patients and BAEPs in 10/21 patients before treatment. In 4 patients with acute optic neuritis (ON), an improvement of VEPs paralleled clinical evolution in 3 cases. Substantial and contrasting changes in VEPs or BAEPs, with no clinical counterpart, were related to a spontaneous fluctuation of EPs in acute relapses of MS. These changes suggest frequent subclinical (multifocal and, possibly, sequential) central nervous system involvement in MS bouts. Group analysis showed nonsignificant changes in EP parameters before and after treatment. Our results indicate that evoked potentials (EPs) are of limited value for monitoring the short-term effect of steroid treatment in MS in bouts.
对21例急性复发期的多发性硬化症（MS）患者在类固醇治疗前后记录了视觉诱发电位（VEP）和脑干听觉诱发电位（BAEP）。治疗前，21例患者中有14例VEP异常，10例BAEP异常。在4例急性视神经炎（ON）患者中，3例VEP的改善与临床病程平行。VEP或BAEP出现显著且相反的变化，但无临床对应表现，这与MS急性复发期诱发电位的自发波动有关。这些变化提示在MS发作时中枢神经系统频繁出现亚临床（多灶性且可能是相继性）受累。组分析显示治疗前后诱发电位参数无显著变化。我们的结果表明，诱发电位（EPs）在监测MS发作时类固醇治疗的短期效果方面价值有限。
