中药治疗对卵巢反应不良患者累积活产率的影响：以个体化卵母细胞数量标准为导向的患者策略

The Effect of Traditional Chinese Medicine Treatment on the Cumulative Live Birth Rate of Patients with Poor Ovarian Response to the Patient-Oriented Strategies Encompassing Individualized Oocyte Number Criteria.

作者信息

Wang Zhuran, Xiao Ting, Qi Guanglan, Zhong Yue, Zhu Yue

机构信息

Department of Traditional Chinese Medicine, Shenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital (Formerly Shenzhen Zhongshan Urology Hospital), Shenzhen City, Guangdong Province, 518000, People's Republic of China.

出版信息

Int J Womens Health. 2024 Dec 28;16:2377-2386. doi: 10.2147/IJWH.S492333. eCollection 2024.

DOI:10.2147/IJWH.S492333

PMID:39749024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693951/

Abstract

OBJECTIVE

This study analyzed the role of traditional Chinese medicine (TCM) treatment on the cumulative live birth rate (CLBR) in women with poor ovarian response to the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) criteria.

METHODS

This cohort study selected 3347 patients with low ovarian response and divided them into four subgroups according to the POSEIDON criteria: Group 1 (n=947), Group 2 (n=778), Group 3 (n=164), and Group 4 (n=1458). Logistic regression analysis was used to evaluate the role of TCM treatment on the CLBR of patients with poor ovarian response to POSEIDON criteria.

RESULTS

In the unadjusted model, TCM treatment might be related to the heightened CLBR (OR=2.052, 95% CI: 1.745-2.413). After adjusting for the POSEIDON group, a higher CLBR was identified in those with TCM treatment (OR=1.927, 95% CI: 1.615-2.300). In Model 3, covariates including the POSEIDON group, age, body mass index (BMI), anti-mullerian hormone (AMH), and/or antral follicle count (AFC) were adjusted, and TCM treatment was associated with elevated CLBR of patients with poor ovarian response to the POSEIDON criteria (OR=1.905, 95% CI: 1.586-2.289). This suggested that TCM increased CLBR by 19.05% in patients who used TCM compared with those who did not. Subgroup analysis indicated that TCM treatment might increase the CLBR of patients in POSEIDON criteria Group 1 (OR=1.83, 95% CI: 1.33-2.51), indicating that TCM elevated the CLBR by 8.3% in POSEIDON criteria Group 1.

CONCLUSION

TCM treatment was related to increased CLBR in patients with poor ovarian response to the POSEIDON criteria.

摘要

目的

本研究分析了中医治疗对卵巢反应不良女性累积活产率（CLBR）的作用，这些女性符合以患者为导向的策略中包含个体化卵母细胞数量（POSEIDON）标准。

方法

这项队列研究选取了3347例卵巢反应低下的患者，并根据POSEIDON标准将她们分为四个亚组：第1组（n = 947）、第2组（n = 778）、第3组（n = 164）和第4组（n = 1458）。采用逻辑回归分析来评估中医治疗对符合POSEIDON标准的卵巢反应不良患者CLBR的作用。

结果

在未调整模型中，中医治疗可能与CLBR升高有关（比值比[OR]=2.052，95%置信区间[CI]：1.745 - 2.413）。在对POSEIDON组进行调整后，接受中医治疗的患者CLBR更高（OR = 1.927，95% CI：1.615 - 2.300）。在模型3中，对包括POSEIDON组、年龄、体重指数（BMI）、抗苗勒管激素（AMH）和/或窦卵泡计数（AFC）等协变量进行了调整，中医治疗与符合POSEIDON标准的卵巢反应不良患者CLBR升高有关（OR = 1.905，95% CI：1.586 - 2.289）。这表明与未使用中医治疗的患者相比，使用中医治疗的患者CLBR提高了19.05%。亚组分析表明，中医治疗可能会提高POSEIDON标准第1组患者的CLBR（OR = 1.83，95% CI：1.33 - 2.51），这表明在POSEIDON标准第1组中，中医治疗使CLBR提高了8.3%。