Li Na, Zhang Junli, Yu Fei, Ye Fanghang, Tan Wanying, Hao Liyuan, Li Shenghao, Deng Jiali, Hu Xiaoyu
Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Drug Des Devel Ther. 2024 Dec 28;18:6413-6426. doi: 10.2147/DDDT.S503302. eCollection 2024.
In recent years, the incidence of fungal infections has been rising annually, especially among immunocompromised populations, posing a significant challenge to public health. Although antifungal medications provide some relief, the escalating problem of resistance sharply curtails their effectiveness, presenting an urgent clinical dilemma that demands immediate attention. Research has shown that fungal resistance is closely related to quorum sensing (QS), and QS inhibitors (QSIs) are considered an effective solution to this issue. Garlic, as a natural QSI, has demonstrated significant effects in inhibiting fungal growth, preventing biofilm formation, enhancing immunity, and combating resistance. This study explores the potential of garlic in mitigating fungal drug resistance and identifies its key role in inhibiting the QS mechanism, these findings offer a new perspective for the treatment of fungal infections, especially in addressing the increasingly severe problem of resistance. However, the clinical application of garlic still faces several challenges, such as ensuring the standardization of active ingredient extraction, as well as issues of safety and stability. Future research should focus on the QS mechanism and promote interdisciplinary collaboration to develop more natural, effective, and safe QSI drugs like garlic, while actively conducting clinical trials to validate their efficacy and safety. Additionally, incorporating advanced technologies such as nanotechnology to enhance drug stability and targeting, provide a more comprehensive strategy for the treatment of fungal infections. Overall, Our study provides scientific evidence supporting the potential of garlic as a novel antifungal treatment and lays the groundwork for the development of future natural QSIs for therapeutic use. It offers new insights, particularly for the treatment of immunocompromised populations and drug-resistant fungal strains.
近年来，真菌感染的发病率逐年上升，尤其是在免疫功能低下的人群中，这对公共卫生构成了重大挑战。尽管抗真菌药物能提供一定缓解，但耐药性问题的不断升级严重削弱了它们的有效性，带来了亟待关注的临床困境。研究表明，真菌耐药性与群体感应（QS）密切相关，群体感应抑制剂（QSIs）被认为是解决这一问题的有效办法。大蒜作为一种天然的群体感应抑制剂，在抑制真菌生长、防止生物膜形成、增强免疫力和对抗耐药性方面已显示出显著效果。本研究探讨了大蒜在减轻真菌耐药性方面的潜力，并确定了其在抑制群体感应机制中的关键作用，这些发现为真菌感染的治疗提供了新的视角，特别是在应对日益严重的耐药性问题方面。然而，大蒜的临床应用仍面临一些挑战，如确保活性成分提取的标准化，以及安全性和稳定性问题。未来的研究应聚焦于群体感应机制，促进跨学科合作，以开发更多像大蒜这样天然、有效且安全的群体感应抑制剂药物，同时积极开展临床试验以验证其疗效和安全性。此外，引入纳米技术等先进技术来提高药物稳定性和靶向性，为真菌感染的治疗提供更全面的策略。总体而言，我们的研究提供了科学证据，支持大蒜作为一种新型抗真菌治疗方法的潜力，并为未来用于治疗的天然群体感应抑制剂的开发奠定了基础。它提供了新的见解，特别是对于免疫功能低下人群和耐药真菌菌株的治疗。
