Jospe-Kaufman Moriah, Fridman Micha
School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Curr Opin Chem Biol. 2025 Apr;85:102570. doi: 10.1016/j.cbpa.2025.102570. Epub 2025 Feb 17.
The rise in fungal infections, driven by pathogens resistant to the limited scope of antifungal agents available, poses an increasing threat to global health and the economy. Addressing this challenge requires a thorough understanding of the mechanisms of antifungal agents and the development of advanced resistance diagnostic methods. This opinion manuscript highlights recent advancements in antifungal research, with a focus on chemical biology approaches, particularly the development of fluorescent probes derived from various antifungal agents. These probes reveal new aspects of antifungal activity and provide deeper insights into modes of action and resistance mechanisms. Live cell imaging of fungal pathogens labeled with these probes has uncovered novel strategies to enhance antifungal efficacy, understand virulence factors, and detect resistance. These unique small-molecule tools offer powerful new avenues for addressing the fungal infections crisis, harnessing chemical biology approaches to develop innovative solutions to the global challenges posed by fungi.
由于现有抗真菌药物种类有限，病原体产生耐药性导致真菌感染不断增加，这对全球健康和经济构成了日益严重的威胁。应对这一挑战需要深入了解抗真菌药物的作用机制，并开发先进的耐药性诊断方法。这篇观点手稿重点介绍了抗真菌研究的最新进展，特别是化学生物学方法，尤其是源自各种抗真菌药物的荧光探针的开发。这些探针揭示了抗真菌活性的新方面，并为作用模式和耐药机制提供了更深入的见解。用这些探针标记的真菌病原体的活细胞成像揭示了增强抗真菌疗效、了解毒力因子和检测耐药性的新策略。这些独特的小分子工具为应对真菌感染危机提供了强大的新途径，利用化学生物学方法开发创新解决方案，应对真菌带来的全球挑战。
