Yan Fei, Ruan Xi, Tang Qin, Song Guo Lin, Xie Ren Fang, Bao Xing Chen
Department of Clinical Laboratory, The Fourth People's Hospital of Chengdu, Chengdu, China.
Department of Clinical Laboratory The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Front Immunol. 2024 Dec 19;15:1494168. doi: 10.3389/fimmu.2024.1494168. eCollection 2024.
This study aims to explore the pathogenic potential of as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury. This case demonstrates that, despite the absence of obvious external infection sources, invasive procedures, or visible trauma, can induce severe bacteremia in immunocompetent individuals. The patient presented with high fever and systemic inflammatory response, with blood cultures confirming the presence of L. adecarboxylata, and chest imaging showing bilateral lower lobe inflammation. Following treatment with ceftriaxone, the patient's symptoms rapidly improved, and infection markers normalized. This study elucidates the potential mechanisms by which can cause infection in immunocompetent individuals and examines the influence of mental health on infection susceptibility. It provides new insights into the complex relationship between mental illness and infection, highlighting the need for further investigation into how mental health may affect infection risk and its clinical management. In conjunction with existing research, this study discusses how psychological stress and behavioral patterns may increase infection risk and recommends future research to further explore the interplay between mental disorders and infectious diseases.
本研究旨在探讨作为免疫功能正常个体中一种罕见病原体的致病潜力，并分析心理健康状况如何影响感染易感性。我们报告了一例31岁免疫功能正常女性的菌血症病例，该患者在严重抑郁发作期间发生了感染。尽管患者有自我伤害倾向，但全面的体格检查未发现任何外部伤口或损伤迹象。该病例表明，尽管没有明显的外部感染源、侵入性操作或可见创伤，但仍可在免疫功能正常个体中诱发严重菌血症。患者出现高热和全身炎症反应，血培养证实存在脱羧勒克菌，胸部影像学显示双侧下叶炎症。使用头孢曲松治疗后，患者症状迅速改善，感染指标恢复正常。本研究阐明了可在免疫功能正常个体中引起感染的潜在机制，并探讨了心理健康对感染易感性的影响。它为精神疾病与感染之间的复杂关系提供了新的见解，强调需要进一步研究心理健康如何影响感染风险及其临床管理。结合现有研究，本研究讨论了心理压力和行为模式如何增加感染风险，并建议未来的研究进一步探索精神障碍与传染病之间的相互作用。
