a Department of Clinical Microbiology , Copenhagen University Hospital (Rigshospitalet) , Copenhagen , Denmark.
b Department of Cardiothoracic Surgery , Copenhagen University Hospital (Rigshospitalet) , Copenhagen , Denmark.
Infect Dis (Lond). 2019 Mar;51(3):179-188. doi: 10.1080/23744235.2018.1536830. Epub 2018 Nov 29.
Leclercia adecarboxylata is a Gram-negative bacterium belonging to the family Enterobacteriaceae. It has been described as an emerging human pathogen with the potential to cause severe infection in immunocompromised patients. The aim of this study was to describe a clinical case of infection with L. adecarboxylata and give a review of previous reports on infection. We report the presence of L. adecarboxylata in a patient initially admitted to our hospital for a lung transplant. She had diarrhoea, urinary tract infection and pneumonia caused by L. adecarboxylata. The isolate was resistant to trimethoprim-sulfamethoxazole and susceptible to 15 other antibiotics tested. The literature search for previous reports of infection with L. adecarboxylata resulted in 61 publications describing 74 cases. Bacteremia and wound infections were most often described, and only a few cases were fatal. L. adecarboxylata was most often found as a monomicrobial infection in immunocompromised patients, and as part of a polymicrobial infection in immunocompetent patients. The previously described isolates showed a high susceptibility to antibiotics, and treatment was efficient in most cases. Due to similarities in metabolic products, L. adecarboxylata might have been mistaken as Escherichia spp., but with new identification methods such as MALDI-TOF MS, it is possible to obtain a certain identification.
阿克曼氏菌是一种革兰氏阴性菌，属于肠杆菌科。它被描述为一种新出现的人类病原体，有可能在免疫功能低下的患者中引起严重感染。本研究旨在描述一例阿克曼氏菌感染病例，并对以往的感染报告进行综述。我们报告了一名最初因肺移植而入院的患者存在阿克曼氏菌的情况。她患有腹泻、尿路感染和肺炎，这些都是由阿克曼氏菌引起的。该分离株对甲氧苄啶-磺胺甲恶唑耐药，对 15 种其他测试的抗生素敏感。对以往阿克曼氏菌感染报告的文献检索共发现 61 篇描述了 74 例病例的文献。菌血症和伤口感染最为常见，只有少数病例是致命的。阿克曼氏菌通常在免疫功能低下的患者中作为单一微生物感染，在免疫功能正常的患者中作为多微生物感染的一部分。以前描述的分离株对大多数抗生素的敏感性很高，大多数情况下治疗有效。由于代谢产物相似，阿克曼氏菌可能被误认为是大肠埃希氏菌，但通过 MALDI-TOF MS 等新的鉴定方法，可以获得一定的鉴定。
