膜联蛋白A1：缺血性中风的曙光（综述）
Annexin A1: The dawn of ischemic stroke (Review).
作者信息
Tang Chen, Lan Rui, Ma Dong-Rui, Zhao Min, Zhang Yong, Li Hong-Yu, Liu Shuang, Li Bo-Yang, Yang Jie-Li, Yang Hui-Jie, Zhang Zhen-Qiang
机构信息
Department of Encephalopathy, The First Affiliated Hospital of Henan University of Chinese Medicine, The First Clinical Medical College of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China.
Department of Encephalopathy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China.
出版信息
Mol Med Rep. 2025 Mar;31(3). doi: 10.3892/mmr.2024.13427. Epub 2025 Jan 3.
Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration. Evidence indicates that ANXA1 plays a pivotal role in the pathogenesis of ischemic stroke. The present article reviews involvement of ANXA1 in anti‑atherosclerosis, inflammatory processes, blood‑brain barrier protection, platelet aggregation and anti‑apoptotic mechanisms. The potential applications of ANXA1 in treating ischemic stroke are also explored.
缺血性中风是一种普遍存在的临床病症，对全球构成重大挑战。制定创新策略来解决这一问题至关重要。膜联蛋白A1（ANXA1）是膜联蛋白超家族的关键成员，具有多种功能，如抑制炎症因子释放、促进吞噬作用和阻止白细胞迁移。有证据表明，ANXA1在缺血性中风的发病机制中起关键作用。本文综述了ANXA1在抗动脉粥样硬化、炎症过程、血脑屏障保护、血小板聚集和抗凋亡机制中的作用。还探讨了ANXA1在治疗缺血性中风方面的潜在应用。
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