Reid Ro-Jay, Safford Monika, Lambert W Marcus, Bryan Joanna, Pinheiro Laura C, Sterling Madeline R, Bowling C Barrett, Levitan Emily B, Banerjee Samprit, Durant Raegan, Kim Michael, Lau Jennifer D, Goyal Parag
Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Department of Epidemiology and Biostatistics, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
J Gerontol A Biol Sci Med Sci. 2024 Dec 11;80(1). doi: 10.1093/gerona/glae222.
Social risk factors are linked to adverse health outcomes, but their total impact on long-term quality of life is obscure. We hypothesized that a higher burden of social risk factors is associated with greater decline in quality of life over 10 years.
We examined associations between social risk factors count and decline >5 points in (i) physical component summary, and (ii) mental component summary scores from the Short Form-12 among Black and White participants in the Reasons for Geographic and Racial Differences in Stroke study (n = 14 401).
For physical component summary, White participants with 1 social risk factor had relative risk (RR) for decline of 1.14 [95% confidence intervals (CI): 1.07-1.12]. Those with ≥2 social risk factors had RR of 1.26 [95% CI: 1.17-1.35], after adjusting for baseline demographics, health behaviors, medical conditions, medications, and physiological variables. Black participants with 1 social risk factor had RR of 1.03 [95% CI: 0.93-1.15]. Those with ≥2 social risk factors had RR of 1.24 [95% CI: 1.13-1.36]. For mental component summary, White participants with 1 social risk factor had RR for decline of 1.19 [95% CI: 1.04-1.37]. Those with ≥2 social risk factors had RR of 1.47 [95% CI: 1.28-1.68]. Black participants with 1 social risk factor had RR of 1.18 [95% CI: 0.96-1.45]. Those with ≥2 social risk factors had RR of 1.38 [95% CI: 1.14-1.66].
More social risk factors increased the risk of decline of quality of life for Black and White individuals, especially impacting mental health.
社会风险因素与不良健康结局相关，但其对长期生活质量的总体影响尚不清楚。我们假设社会风险因素负担较重与10年内生活质量下降幅度较大有关。
在“中风地理和种族差异原因”研究（n = 14401）中的黑人和白人参与者中，我们研究了社会风险因素数量与（i）身体成分总结得分和（ii）简短健康调查问卷12项身体和精神成分总结得分下降超过5分之间的关联。
对于身体成分总结，有1个社会风险因素的白人参与者下降的相对风险（RR）为1.14 [95%置信区间（CI）：1.07 - 1.12]。在调整基线人口统计学、健康行为、医疗状况、药物和生理变量后，有≥2个社会风险因素的参与者RR为1.26 [95% CI：1.17 - 1.35]。有1个社会风险因素的黑人参与者RR为1.03 [95% CI：0.93 - 1.15]。有≥2个社会风险因素的参与者RR为1.24 [95% CI：1.13 - 1.36]。对于精神成分总结，有1个社会风险因素的白人参与者下降的RR为1.19 [95% CI：1.04 - 1.37]。有≥2个社会风险因素的参与者RR为1.47 [95% CI：1.28 - 1.68]。有1个社会风险因素的黑人参与者RR为1.18 [95% CI：0.96 - 1.45]。有≥2个社会风险因素的参与者RR为1.38 [95% CI：1.14 - 1.66]。
更多的社会风险因素增加了黑人和白人生活质量下降的风险，尤其对心理健康产生影响。
