de Klerk D P, Human H J
Prostate. 1985;6(2):169-75. doi: 10.1002/pros.2990060207.
Mesenchymal glycosaminoglycans have been shown to fluctuate during the development of various organs. Prostatic development is an interesting example of organogenesis as it is only at puberty, under androgen influence, that differentiation is completed. We have extracted and quantitated the glycosaminoglycans of human prostates obtained from fetuses, prepubertal, and adult males to determine the changes that occur during prostatic differentiation. The total glycosaminoglycan content per prostate followed the wet weight growth curve. The percentages of heparan sulfate and heparan sulfate sulfation seemed to correlate with prostatic epithelial differentiation. After 25 years of age prostatic glycosaminoglycan concentrations tend toward the glycosaminoglycan ratios typical of benign prostatic hyperplasia.
间充质糖胺聚糖已被证明在各种器官的发育过程中会发生波动。前列腺发育是器官发生的一个有趣例子，因为只有在青春期，在雄激素的影响下，分化才会完成。我们提取并定量了从胎儿、青春期前男性和成年男性获得的人类前列腺中的糖胺聚糖，以确定前列腺分化过程中发生的变化。每个前列腺的总糖胺聚糖含量遵循湿重生长曲线。硫酸乙酰肝素和硫酸乙酰肝素硫酸化的百分比似乎与前列腺上皮分化相关。25岁以后，前列腺糖胺聚糖浓度趋向于良性前列腺增生典型的糖胺聚糖比例。
