De Klerk D P, Lee D V, Human H J
J Urol. 1984 May;131(5):1008-12. doi: 10.1016/s0022-5347(17)50750-8.
The glycosaminoglycans of normal, benign hyperplastic and cancerous prostate were studied. In both prostatic hyperplasia and cancer the chondroitin sulfate:dermatan sulfate ratio was increased. In prostatic cancer this increase correlated with both the differentiation and extent of cancer in the prostate. The percentages heparan sulfate and heparan sulfate sulfation were decreased in prostatic cancer. Hyaluronic acid increased with dedifferentiation of the cancer. Histochemically, sulfated glycosaminoglycans were concentrated in the prostatic stroma at the stromal-epithelial interface. The increased chondroitin sulfate:dermatan sulfate ratio may be a nonspecific response or requirement for epithelial growth.
对正常、良性增生和癌性前列腺组织中的糖胺聚糖进行了研究。在前列腺增生和癌症中，硫酸软骨素与硫酸皮肤素的比例均升高。在前列腺癌中，这种升高与前列腺癌的分化程度和范围均相关。前列腺癌中硫酸乙酰肝素及其硫酸化的百分比降低。透明质酸随着癌症的去分化而增加。组织化学研究表明，硫酸化糖胺聚糖集中在前列腺基质与上皮的交界处。硫酸软骨素与硫酸皮肤素比例的增加可能是上皮生长的一种非特异性反应或需求。
