Silva Régia Carla Medeiros da, Silva Lucas Gabriel Cunha da, Cruz Natália Teixeira da Silva, Barbosa Ádylla Rominne Lima, Maia Paulo Raphael Leite, Martins Ana Rafaela Luz de Aquino
Federal University of Rio Grande do Norte, Natal, Brazil.
Lasers Med Sci. 2025 Jan 3;40(1):6. doi: 10.1007/s10103-024-04275-w.
To assess and compare two techniques of low-level laser application-transgingival (TLLLT) and intrasulcular (ILLLT)-used in photobiomodulation as an adjunct to basic periodontal therapy (BPT) in patients with periodontitis. A randomized, split-mouth, double-blind clinical trial was conducted, selecting three diseased periodontal sites from different quadrants in each patient. These sites were assigned to one of three treatment groups: SRP (control), SRP + TLLLT (test 1), and SRP + ILLLT (test 2). Low-level laser therapy in the test groups was applied at 48 h, 7 days, and 14 days after full-mouth SRP. Clinical parameters such as probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were assessed at baseline (T0), 3 months (T1), and 6 months (T2). Standardized periapical radiographs were used to assess radiographic bone density (RBD) 6 months post-treatment. Statistical analyses included repeated measures ANOVA for continuous variables and chi-square tests for categorical variables, with significance set at p < 0.05 and a 95% confidence interval. Significant reductions in PD (p < 0.001) and CAL (p < 0.001) were observed across all groups at 3 and 6 months, with no significant differences between groups. There were also no significant changes in BOP and RBD between groups at the follow-up intervals. Adjunctive photobiomodulation did not provide additional clinical or radiographic benefits over SRP alone, regardless of the laser application technique employed.
评估和比较两种低强度激光应用技术——经龈（TLLLT）和龈沟内（ILLLT）——在牙周炎患者中作为基础牙周治疗（BPT）辅助手段用于光生物调节的效果。进行了一项随机、分口、双盲临床试验，在每位患者的不同象限选择三个患病牙周部位。这些部位被分配到三个治疗组之一：SRP（对照组）、SRP + TLLLT（试验1）和SRP + ILLLT（试验2）。试验组的低强度激光治疗在全口SRP后48小时、7天和14天进行。在基线（T0）、3个月（T1）和6个月（T2）时评估临床参数，如探诊深度（PD）、临床附着水平（CAL）和探诊出血（BOP）。使用标准化根尖片在治疗后6个月评估放射学骨密度（RBD）。统计分析包括对连续变量的重复测量方差分析和对分类变量的卡方检验，显著性设定为p < 0.05和95%置信区间。在3个月和6个月时，所有组的PD（p < 0.001）和CAL（p < 0.001）均显著降低，组间无显著差异。在随访期间，组间BOP和RBD也无显著变化。无论采用何种激光应用技术，辅助光生物调节相较于单独的SRP并未提供额外的临床或放射学益处。
