Sousa-Fraguas M C, Rodríguez-Fuentes G, Lastra-Barreira D, Conejo N M
Department of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Health Sciences, University of Oviedo, Oviedo, 33006, Spain.
Faculty of Physiotherapy, Department of Surgery and Medical-Surgical Specialties, University of Oviedo, Oviedo, E-33006, Spain.
Aging Clin Exp Res. 2025 Jan 3;37(1):19. doi: 10.1007/s40520-024-02922-4.
The presence of frailty is common in people with Parkinson's disease, as is cognitive dysfunction. Previous research on frailty has focused on the physical aspects of the pathology.
To analyze the relationship between frailty and cognitive impairment in patients with Parkinson's disease and to know which disease characteristics are associated with frailty.
An observational, correlational and cross-sectional study was conducted. Participants were recruited from a Home Rehabilitation Service and two Parkinson's Associations. An individualized assessment was carried out by means of a structured interview. Frailty was assessed with the Fried scale and cognitive function with the Mini Mental State Examination and the Parkinson's Disease Cognitive Rating Scale.
90 patients were recruited, 60% men, with a mean age of 73.50 (6.71) years. Frailty was associated with age and disease severity (p < 0.05). Frail patients presented worse cognitive performance relative to pre-frail and robust patients. A negative correlation (coefficient - 0.503) was observed between frailty and measures of patients' cognitive function (p < 0.05).
The coexistence of frailty and cognitive impairment should be assessed, as PD patients with both conditions are more vulnerable and have a higher chance of experiencing adverse effects.
Frail patients with Parkinson's disease present an impairment of cognitive functions dependent on cortical and subcortical regions, being these regions more preserved in the case of robust. The development of programs for early detection of frailty and cognitive function in these patients is necessary to implement strategic intervention plans focused on reversing frailty and cognitive impairment. PROTOCOL REGISTRATION NUMBER: http://www.
gov ID: NCT05388526.
衰弱在帕金森病患者中很常见，认知功能障碍也是如此。先前关于衰弱的研究主要集中在病理学的身体方面。
分析帕金森病患者衰弱与认知障碍之间的关系，并了解哪些疾病特征与衰弱相关。
进行了一项观察性、相关性和横断面研究。参与者从家庭康复服务机构和两个帕金森病协会招募。通过结构化访谈进行个体化评估。采用弗里德量表评估衰弱，采用简易精神状态检查表和帕金森病认知评定量表评估认知功能。
共招募了90名患者，男性占60%，平均年龄为73.50（6.71）岁。衰弱与年龄和疾病严重程度相关（p < 0.05）。相对于非衰弱和强健的患者，衰弱患者的认知表现更差。在衰弱与患者认知功能指标之间观察到负相关（系数为 - 0.503）（p < 0.05）。
应评估衰弱和认知障碍的共存情况，因为同时患有这两种疾病的帕金森病患者更易受到伤害，且出现不良反应的几率更高。
帕金森病衰弱患者存在依赖于皮质和皮质下区域的认知功能损害，而在强健患者中这些区域保存得更好。有必要制定针对这些患者衰弱和认知功能早期检测的项目，以实施旨在逆转衰弱和认知障碍的战略干预计划。方案注册号：http://www.
政府标识符：NCT05388526。
