Department of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Health Sciences, University of Oviedo, 33006, Oviedo, Spain.
Department of Functional Biology and Health Sciences, Faculty of Physiotherapy, Universidade de Vigo, 36005, Pontevedra, Spain.
Neurol Sci. 2022 Dec;43(12):6693-6706. doi: 10.1007/s10072-022-06347-7. Epub 2022 Sep 2.
Frailty can lead to increased vulnerability in older people and patients with Parkinson's disease (pwPD) and worsen their health conditions. These patients can also develop cognitive function impairment. The objective is to analyze whether there is a relationship between frailty and cognitive impairment in pwPD, and to find out which instruments to use for its evaluation.
Publications were searched in PubMed, Medline, Web of Science, Cinalh, Cochrane Library, Embase, Phycinfo, and Scopus. The results were measured with the instruments that are used to assess frailty and cognitive impairment, and analyze their relationship.
Two hundred seventy-one articles were identified, of which 12 met the inclusion criteria. All studies assessed frailty and cognitive function in pwPD. Five studies analyzed the relationship between frailty and cognitive impairment. The most used instruments were the Fried scale followed by the Clinical Frailty Scale (CFS) for frailty. Cognitive impairment was mostly evaluated with the Mini-Mental State Examination and the Montreal Cognitive Assessment. The prevalence data ranged from 20.2 to 51.5% with the Fried scale and from 35.6 to 83.9% with the CFS. Cognitive impairment was present in 15 to 45.2% of the pwPD.
Analysis of the included studies shows a relationship between frailty and cognitive impairment in pwPD. There was significant variability in the application of the scales used, which influences the prevalence data. More observational and experimental studies are needed to provide more evidence on this association and to determine which is the optimal tool to identify frailty in pwPD using multidimensional scales.
衰弱可导致老年人和帕金森病患者（pwPD）的脆弱性增加，并使他们的健康状况恶化。这些患者还可能出现认知功能障碍。目的是分析 pwPD 中衰弱与认知障碍之间是否存在关系，并找出评估衰弱的工具。
在 PubMed、Medline、Web of Science、Cinalh、Cochrane Library、Embase、Phycinfo 和 Scopus 中搜索出版物。使用评估衰弱和认知障碍的工具来衡量结果，并分析它们之间的关系。
确定了 271 篇文章，其中 12 篇符合纳入标准。所有研究均评估了 pwPD 的衰弱和认知功能。五项研究分析了衰弱和认知障碍之间的关系。最常用的工具是 Fried 量表，其次是临床衰弱量表（CFS）用于评估衰弱。认知障碍主要用简易精神状态检查和蒙特利尔认知评估进行评估。使用 Fried 量表时，衰弱的患病率数据范围为 20.2%至 51.5%，使用 CFS 时，衰弱的患病率数据范围为 35.6%至 83.9%。pwPD 中有 15%至 45.2%存在认知障碍。
对纳入研究的分析表明，pwPD 中衰弱与认知障碍之间存在关系。所使用量表的应用存在显著差异，这影响了患病率数据。需要更多的观察性和实验性研究来提供更多关于这种关联的证据，并确定使用多维量表识别 pwPD 衰弱的最佳工具。
