Gerardo Gina, Peterson Ninoska, Goodpaster Kasey, Heinberg Leslie
Cleveland Clinic Metabolic and Bariatric Institute, Cleveland, OH, USA.
Curr Obes Rep. 2025 Jan 3;14(1):5. doi: 10.1007/s13679-024-00603-x.
To summarize the recent literature regarding the interaction between the public health concerns of obesity and depression and provide preliminary recommendations for assessment and management of patients with co-occurring obesity and depression. RECENT FINDINGS : Recent studies have reinforced that while there is a bi-directional link between obesity and depression, there is stronger evidence that obesity contributes to the development of depression. Recent research has also elucidated potential mediating factors in the association between depression and obesity (e.g., demographical, biological, and psychological) as well as a moderating effect of treatment of depression on outcomes for treatment of obesity. There is evidence to suggest that in co-occurring depression and obesity, it is beneficial to treat depression first. Cognitive behavioral therapies have demonstrated effectiveness in treating co-occurring depression and obesity and there is preliminary evidence suggesting that increasing emotion regulation and reducing weight bias internalization may be important treatment targets.
总结近期关于肥胖与抑郁的公共卫生问题之间相互作用的文献，并为肥胖与抑郁共病患者的评估和管理提供初步建议。近期研究结果：近期研究进一步证实，虽然肥胖与抑郁之间存在双向联系，但有更强的证据表明肥胖会导致抑郁的发生。近期研究还阐明了抑郁与肥胖之间关联的潜在中介因素（如人口统计学、生物学和心理学因素），以及抑郁治疗对肥胖治疗结果的调节作用。有证据表明，在抑郁与肥胖共病的情况下，先治疗抑郁是有益的。认知行为疗法已证明对治疗抑郁与肥胖共病有效，且有初步证据表明，增强情绪调节和减少体重偏见内化可能是重要的治疗靶点。
