美国成年人幽门螺杆菌感染与甘油三酯-葡萄糖（TyG）指数之间的关联：一项回顾性横断面研究。
The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study.
作者信息
Fu Wei, Zhao Junlong, Chen GuoBin, Lyu Linya, Ding Yao, Xu Liang-Bi
机构信息
Department of Gastroenterology, 925th Hospital of PLA Joint Logistics Support Force, Guiyang, China.
Department of Medical Genetics and Developmental Biology, State Key Laboratory of Cancer Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
出版信息
PLoS One. 2025 Jan 3;20(1):e0295888. doi: 10.1371/journal.pone.0295888. eCollection 2025.
BACKGROUND
The Triglyceride-glucose (TyG) index is a marker for insulin resistance and metabolic syndrome, while Helicobacter pylori is linked to gastrointestinal diseases and may affect metabolic risks. This study examined the association between the TyG index and H. pylori infection in adults.
METHODS
Data from 3797 participants in the NHANES 1999-2000 cycle were analyzed. The relationship between the TyG index and H. pylori infection was assessed using multivariate logistic regression and a two-piecewise logistic model to explore non-linear effects. Subgroup analyses were conducted based on age, sex, glucose levels, BMI, and CKD.
RESULTS
A linear association between the TyG index and H. pylori infection was found. Subgroup analyses revealed significant interactions with a few variables.
CONCLUSIONS
This study indicates a linear relationship between the TyG index and H. pylori infection, suggesting metabolic influences on H. pylori infection and potential for targeted interventions in at-risk groups.
背景
甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗和代谢综合征的一个标志物，而幽门螺杆菌与胃肠道疾病有关，并且可能影响代谢风险。本研究调查了成年人中TyG指数与幽门螺杆菌感染之间的关联。
方法
分析了来自1999 - 2000年美国国家健康与营养检查调查（NHANES）周期中3797名参与者的数据。使用多变量逻辑回归和两段式逻辑模型评估TyG指数与幽门螺杆菌感染之间的关系，以探索非线性效应。基于年龄、性别、血糖水平、体重指数（BMI）和慢性肾脏病（CKD）进行亚组分析。
结果
发现TyG指数与幽门螺杆菌感染之间存在线性关联。亚组分析揭示了与一些变量的显著交互作用。
结论
本研究表明TyG指数与幽门螺杆菌感染之间存在线性关系，提示代谢对幽门螺杆菌感染的影响以及对高危人群进行针对性干预的可能性。
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