Liu Wei, An Jie, Jiao Cheng, Guo Jun, Zhang Lipu, Jin Haifeng, Liu Guangchao, Zhang Yao
Department of General Surgery, Bethune International Peace Hospital, No. 398 Zhongshan West Road, Qiaoxi District, Shijiazhuang, Hebei, China.
Department of Pathology, Bethune International Peace Hospital, No. 398 Zhongshan West Road, Qiaoxi District, Shijiazhuang, Hebei, China.
Sci Rep. 2025 Jan 2;15(1):387. doi: 10.1038/s41598-024-84536-4.
Helicobacter pylori (H. pylori) infection is linked to metabolic syndrome and insulin resistance, with the triglyceride-glucose (TyG) index serving as a reliable marker for the latter. This study investigates the association between the TyG index and H. pylori infection. The study utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2000. Participants underwent serologic testing for H. pylori, and the TyG index was calculated from fasting laboratory measurements. Multivariate logistic regression and restricted cubic spline methods were used to assess the association and explore the dose-response relationship. The analysis included 2984 participants. Elevated TyG index values were associated with an increased likelihood of H. pylori infection. The risk of infection rose with higher TyG index quartiles, with the highest quartile showing the most significant increase (OR = 1.54, 95% CI: 1.15-2.07, P = 0.004). A linear relationship between the TyG index and H. pylori infection was demonstrated. The study findings indicate a significant positive association between the TyG index and H. pylori infection. This association highlights the importance of metabolic health in the context of H. pylori infection and suggests that further research is needed to explore the potential implications for health promotion strategies.
幽门螺杆菌（H. pylori）感染与代谢综合征和胰岛素抵抗有关，甘油三酯-葡萄糖（TyG）指数是后者的可靠标志物。本研究调查了TyG指数与幽门螺杆菌感染之间的关联。该研究利用了1999年至2000年期间进行的美国国家健康与营养检查调查（NHANES）的横断面数据。参与者接受了幽门螺杆菌的血清学检测，并根据空腹实验室测量结果计算TyG指数。采用多因素逻辑回归和受限立方样条方法评估关联并探索剂量反应关系。分析纳入了2984名参与者。TyG指数升高与幽门螺杆菌感染的可能性增加有关。感染风险随着TyG指数四分位数的升高而增加，最高四分位数显示出最显著的增加（比值比=1.54，95%置信区间：1.15-2.07，P=0.004）。TyG指数与幽门螺杆菌感染之间呈现线性关系。研究结果表明TyG指数与幽门螺杆菌感染之间存在显著的正相关。这种关联凸显了在幽门螺杆菌感染背景下代谢健康的重要性，并表明需要进一步研究以探索其对健康促进策略的潜在影响。
