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碳纳米管的治疗方法:革新生物医学和制药领域的纳米材料。

Therapeutic approach of carbon nanotube: Revolutionize nanomaterial in biomedical and pharmaceutical sector.

作者信息

Ghosh Shovan, Dave Vivek, Wal Pranay

机构信息

Department of Pharmacy, School of Health Science, Central University of South Bihar, Bihar, India.

Pranveer Singh Institute of Technology, Pharmacy, Kanpur, India.

出版信息

J Food Drug Anal. 2024 Dec 15;32(4):412-427. doi: 10.38212/2224-6614.3531.

Abstract

Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier molecules due to the presence of impurities, so purification is an essential aspect of their use. In addition, various functionalization procedures are used frequently for drug conjugation with other benefits, such as reduced toxicity and targeted delivery. Their nano needle structure can penetrate any cell without damaging it with improved efficiency in targeted drug delivery, cancer cell identification, anticancer molecule delivery, antifungal treatment, and transdermal approaches. This nanostructure also has some antimicrobial activity, and conjugation with some antimicrobial agents shows a synergistic response.

摘要

碳纳米管(CNTs)因其独特的结构、机械、电学和热学性质,已成为一种具有广泛潜在应用前景的纳米材料。然而,碳纳米管要成功应用,必须克服众多障碍,包括低溶解度、聚集以及缺乏特定功能等问题。为克服这些问题,人们已开发出多种用于碳纳米管制造、纯化和功能化的技术。这篇综述文章的主要目的是简要介绍碳纳米管以及在药物递送中使用这种变革性纳米材料的策略。由于存在杂质,制备好的碳纳米管不能直接用作药物载体分子,因此纯化是其应用的一个重要方面。此外,各种功能化程序经常用于药物偶联,还有其他益处,如降低毒性和靶向递送。它们的纳米针结构可以穿透任何细胞而不造成损伤,在靶向药物递送、癌细胞识别、抗癌分子递送、抗真菌治疗和透皮给药等方面具有更高的效率。这种纳米结构还具有一定的抗菌活性,与一些抗菌剂偶联显示出协同反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a66/11698598/d4303491f6c4/jfda-32-04-412f1.jpg

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