Duan Xuwei, Xu Jian, Liu Xueqin, Wang Duoping, Chen Biaoyou
Guangxi Medical University Cancer Hospital, Department of Head and neck Surgery, Nanning, China.
Guangxi Medical University Cancer Hospital, Department of Head and neck Surgery, Nanning, China.
Braz J Otorhinolaryngol. 2025 Mar-Apr;91(2):101537. doi: 10.1016/j.bjorl.2024.101537. Epub 2025 Jan 3.
Pharyngocutaneous Fistula (PCF) is one of the most common and challenging postoperative complications after Total Laryngectomy (TLE). This study aimed to evaluate the impact of the modified Vertical Pressure Bandage (VPB) on the occurrence of Pharyngocutaneous Fistula (PCF) after Total Laryngectomy (TLE) for Head and Neck (H&N) cancer.
This retrospective study included patients with H&N cancer who underwent TLE at our hospital between January 2010 and January 2021. The patients were grouped according to whether modified VPB was used or not after surgery. The primary outcome was the occurrence of PCF. The secondary outcomes were the interval from operation to PCF, the healing time of PCF, and the length of hospital stay.
This study included 133 patients: 82 (aged 57.93 ± 10.18 years, 80 males) in the VPB group and 51 (aged 54.98 ± 9.22 years, 51 males) in the conventional group. Patients who received the modified VPB had a significantly lower occurrence of PCF compared with those did not (9.8% vs. 33.3%, p = 0.001). In addition, the patients in the VPB group had similar interval from the operation to the PCF (p = 0.374) and healing time of PCF (p = 0.256) but a significantly shorter length of hospital stay (p < 0.001) compared with those in conventional group. Moreover, multivariable logistic regression analysis showed that, after adjusting for age, preoperative radiotherapy, postoperative hematocrit < 35%, VPB (RR = 0.165, 95% CI 0.057‒0.474, p = 0.001) was an independent protective factor for PCF.
The modified VPB might reduce the occurrence of PCF after TLE for H&N cancers.
Level 4.
咽皮肤瘘(PCF)是全喉切除术(TLE)后最常见且具有挑战性的术后并发症之一。本研究旨在评估改良垂直压力绷带(VPB)对头颈(H&N)癌全喉切除术后咽皮肤瘘(PCF)发生情况的影响。
本回顾性研究纳入了2010年1月至2021年1月期间在我院接受全喉切除术的头颈癌患者。患者根据术后是否使用改良VPB进行分组。主要结局是咽皮肤瘘的发生情况。次要结局包括从手术到咽皮肤瘘的间隔时间、咽皮肤瘘的愈合时间以及住院时间。
本研究共纳入133例患者:VPB组82例(年龄57.93±10.18岁,男性80例),传统组51例(年龄54.98±9.22岁,男性51例)。接受改良VPB的患者咽皮肤瘘的发生率显著低于未接受改良VPB的患者(9.8%对33.3%,p = 0.001)。此外,与传统组相比,VPB组患者从手术到咽皮肤瘘的间隔时间(p = 0.374)和咽皮肤瘘的愈合时间(p = 0.256)相似,但住院时间显著缩短(p < 0.001)。此外,多变量逻辑回归分析显示,在调整年龄、术前放疗、术后血细胞比容<35%后,VPB(相对风险 = 0.165,95%置信区间0.057 - 0.474,p = 0.001)是咽皮肤瘘的独立保护因素。
改良VPB可能会降低头颈癌全喉切除术后咽皮肤瘘的发生率。
4级。