Hochstadt Jan, Martínez Pacheco Sarai, Casanova-Acebes María
Cancer Immunity Laboratory, Molecular Oncology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Cancer Immunity Laboratory, Molecular Oncology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Trends Cancer. 2025 Apr;11(4):351-364. doi: 10.1016/j.trecan.2024.12.002. Epub 2025 Jan 2.
Macrophages are myeloid cells that receive, integrate, and respond to tumoral cues. Tumors evolve and are shaped by macrophages, with tumor-associated macrophage (TAM)-tumor sculpting capacities going beyond an increase in their cellular mass. Longitudinal and local heterogeneity of TAM states is now possible with the use of single-cell and spatial transcriptomics. However, understanding TAM biology and its fundamental functional programs is still challenging, probably because of the lack of models that fully integrate TAM complexity. Here, we aim to review TAM diversity not only at the level of single-cell phenotypes but also by integrating complex physiological signals that determine their complexity and plasticity in tumors.
巨噬细胞是一种髓系细胞，可接收、整合肿瘤信号并做出反应。肿瘤在巨噬细胞的作用下不断演变和塑形，肿瘤相关巨噬细胞（TAM）对肿瘤的塑造能力不仅仅体现在细胞数量的增加上。借助单细胞和空间转录组学技术，现在能够研究TAM状态的纵向和局部异质性。然而，理解TAM生物学及其基本功能程序仍然具有挑战性，这可能是因为缺乏能够充分整合TAM复杂性的模型。在这里，我们旨在不仅从单细胞表型层面，而且通过整合决定其在肿瘤中复杂性和可塑性的复杂生理信号，来综述TAM的多样性。
