Qin Yu, Chen Linlin, Zheng Liyan
Chongqing Engineering Research Center of Pharmaceutical Sciences, Pharmacy College, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.
School of Pharmacy, QuanZhou Medical College, Quanzhou, 362000, Fujian, China.
Sci Rep. 2025 Jan 3;15(1):604. doi: 10.1038/s41598-024-82782-0.
It has been reported some nanozymes could be used as a substitute for natural enzyme to detect HO to some extent. However, the low catalytic effect of these materials limited their further application fields. Hence, to increase the catalytic activity of nanozymes was a hot research topic and many methods have been reported. Among them, surface modification was an important and efficient approach due to the surface of nanomaterials could affect their properties. In this article, three amino acid modified Cu-MOPs: H-Cu-MOP-Glutamine, H-Cu-MOP-Leucine and H-Cu-MOP-Isoleucine were obtained by further coordination interactions of carboxyl group with copper ions. Compared with H-Cu-MOP, the modified Cu-MOP exhibited a higher catalytic activity and a more stable color change, which could broaden its potential application field. Due to its excellent peroxidase activity, H-Cu-MOP-Leucine can be used to detect potassium guaiacol sulfonate with good anti-interference properties. It exhibits a favorable linear range of 5.0 × 10-1.0 × 10 M, and the limit of detection is 1.28 × 10 M, making it suitable for practical applications. The above results indicate that post-modification of MOP can effectively improve its performance, providing a viable strategy for broadening the practical application of MOP in the detection field.
据报道，一些纳米酶在一定程度上可作为天然酶的替代品来检测过氧化氢。然而，这些材料的低催化效果限制了它们进一步的应用领域。因此，提高纳米酶的催化活性是一个热门研究课题，并且已经报道了许多方法。其中，表面修饰是一种重要且有效的方法，因为纳米材料的表面会影响其性能。在本文中，通过羧基与铜离子的进一步配位相互作用，获得了三种氨基酸修饰的金属有机框架材料（Cu-MOFs）：H-Cu-MOF-谷氨酰胺、H-Cu-MOF-亮氨酸和H-Cu-MOF-异亮氨酸。与H-Cu-MOF相比，修饰后的Cu-MOF表现出更高的催化活性和更稳定的颜色变化，这可以拓宽其潜在应用领域。由于其优异的过氧化物酶活性，H-Cu-MOF-亮氨酸可用于检测愈创木酚磺酸钾，具有良好的抗干扰性能。它呈现出5.0×10⁻¹.0×10⁻⁶M的良好线性范围，检测限为1.28×10⁻⁷M，使其适用于实际应用。上述结果表明，对金属有机框架材料进行后修饰可以有效提高其性能，为拓宽金属有机框架材料在检测领域的实际应用提供了一种可行的策略。
