Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Chem Soc Rev. 2021 Jan 7;50(1):39-57. doi: 10.1039/d0cs00344a. Epub 2020 Nov 11.
Amino acid modification plays an important role across several fields, including synthetic organic chemistry, materials science, targeted drug delivery and the probing of biological function. Although a myriad of methods now exist for the modification of peptides or proteins, many of these target a handful of the most reactive proteinogenic amino acids. Photocatalysis has recently emerged as a mild approach for amino acid modification, generating a sizable toolbox of reactions capable of modifying almost all of the canonical amino acids. These reactions are characterised by their mild, physiologically compatible conditions, greatly enhancing their usefulness for amino acid modification. This review aims to introduce the field of photocatalytic amino acid modification and discusses the most recent advances.
氨基酸修饰在多个领域都发挥着重要作用，包括合成有机化学、材料科学、靶向药物传递和生物功能探测。尽管现在有许多方法可以修饰肽或蛋白质，但其中许多方法只针对少数最具反应性的天然氨基酸。光催化最近成为一种温和的氨基酸修饰方法，产生了大量的反应工具箱，能够修饰几乎所有的典型氨基酸。这些反应的特点是温和、生理相容的条件，大大提高了它们在氨基酸修饰中的有用性。本文旨在介绍光催化氨基酸修饰领域，并讨论最新进展。
