Chen Zhenshuo, Luo Yunfei, Liu Jianping
Jiangxi Medical College, Nanchang University, Nanchang, China.
Department of Metabolism and Endocrinology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Hum Cell. 2025 Jan 3;38(2):39. doi: 10.1007/s13577-024-01171-x.
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its complications. Human amniotic epithelial stem cells (HAESCs), originate from the innermost layer of the placenta closest to the fetus and express stem cell markers in the amniotic membrane's umbilical cord attachment area, which have garnered significant attention. This article critically examines emerging research advancements and potential application values of hAESCs in treating diabetes and its complications. Initially, we will discuss the characteristics, origin, and advantages of hAESCs in differentiating into insulin-secreting cells. Subsequently, we will focus on the potential applications of hAESCs in treating diabetes complications such as diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, etc. We will scrutinize the progress of relevant clinical studies and trials involving hAESC therapy. In conclusion, as an emerging diabetes treatment method, hAESCs exhibit immense potential and application value. Despite numerous challenges in practical application, we are confident that with scientific advancement and technological progress, hAESCs will play a pivotal role in treating diabetes and its related complications.
糖尿病患病率的不断上升，引发了人们对该疾病及其并发症创新治疗策略的浓厚兴趣。人羊膜上皮干细胞（HAESCs）起源于胎盘最靠近胎儿的最内层，并在羊膜脐带附着区域表达干细胞标志物，这已引起了广泛关注。本文批判性地审视了人羊膜上皮干细胞在治疗糖尿病及其并发症方面的新兴研究进展和潜在应用价值。首先，我们将讨论人羊膜上皮干细胞在分化为胰岛素分泌细胞方面的特征、起源和优势。随后，我们将重点关注人羊膜上皮干细胞在治疗糖尿病并发症如糖尿病视网膜病变、糖尿病肾病和糖尿病神经病变等方面的潜在应用。我们将仔细研究涉及人羊膜上皮干细胞治疗的相关临床研究和试验的进展。总之，作为一种新兴的糖尿病治疗方法，人羊膜上皮干细胞展现出巨大的潜力和应用价值。尽管在实际应用中存在诸多挑战，但我们相信随着科学进步和技术发展，人羊膜上皮干细胞将在治疗糖尿病及其相关并发症中发挥关键作用。
