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白蒿(Artemisia herba Alba)对肉牛捻转血矛线虫的驱虫活性。

The anthelmintic activity of the white wormwood (Artemisia herba Alba) against Haemonchus contortus in beef cattle.

作者信息

Hoshiki Annamore, Soul Washaya, Bernard Nyamushamba Godfrey

机构信息

Department of Agriculture, Women's University in Africa, 549 Arcturus Road, Harare, Zimbabwe.

Gary Magadzire School of Agriculture, Department of Livestock, Wildlife, and Fisheries, Great Zimbabwe University, P O Box 1325, Masvingo, Zimbabwe.

出版信息

Sci Rep. 2025 Jan 3;15(1):637. doi: 10.1038/s41598-024-84656-x.

Abstract

The objective of the study was to determine the efficacy of white wormwood on helminthes in beef cattle production. Water extracts of white wormwood of different levels of phytotoxicity were used to treat female adult H. contortus over 8 h under controlled laboratory conditions. The experiment was designed in a completely randomized design with six treatments replicated three times. Treatments 3-6 showed a reduction in worm motility over time (P < 0.05) while it did not change much for T1 and T2 (P < 0.05). Even after 8 h of incubation, more than 50% of the worms were still active in T1, T2 and T3. Meaningful reductions in activity were observed in T4 from 6 to 8 h, T5 form 4-8 h and T6 form 2-6 h. The highest mortality was observed in T4, T5 and T6, 8 h after incubation, however only T6 totally killed all worms 6 h after incubation. Treatments 4 and 5 only achieved 80 and 82% mortality respectively, 8 h post incubation. It is therefore concluded that wormwood aqueous extracts at 5 mg/mL and 10 mg/mL have the capability to immobilize, inactivate and kill mature H. contortus worms from beef cattle.

摘要

本研究的目的是确定白蒿对肉牛生产中蠕虫的疗效。在可控的实验室条件下,使用不同植物毒性水平的白蒿水提取物对成年雌性捻转血矛线虫进行8小时的处理。实验采用完全随机设计,有六种处理,重复三次。处理3 - 6的蠕虫活力随时间下降(P < 0.05),而处理1和处理2变化不大(P < 0.05)。即使在孵育8小时后,处理1、处理2和处理3中仍有超过50%的蠕虫活跃。在处理4中,6至8小时观察到活力有显著下降;处理5在4至8小时、处理6在2至6小时观察到活力有显著下降。孵育8小时后,处理4、处理5和处理6的死亡率最高,然而只有处理6在孵育6小时后完全杀死了所有蠕虫。孵育8小时后,处理4和处理5的死亡率分别仅达到80%和82%。因此得出结论,5毫克/毫升和10毫克/毫升的白蒿水提取物有能力使肉牛体内成熟的捻转血矛线虫蠕虫固定、失活并杀死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecac/11698843/e140fb971663/41598_2024_84656_Fig1_HTML.jpg

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