Kaye Alan D, Cheon Se Yun, Roque Morgan H, Gibbs Caroline, Mott Karlee R, Wandler Alex M, Munir Syeda T, Lin Junyu, Ahmadzadeh Shahab, Siddaiah Harish, Myers Sarah H, Bembenick Kristin Nicole, Shekoohi Sahar
Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Tulane School of Medicine, New Orleans, LA, USA.
Curr Pain Headache Rep. 2025 Jan 4;29(1):9. doi: 10.1007/s11916-024-01310-x.
Baclofen, a muscle relaxant that reduces the release of excitatory neurotransmitters in the pre-synaptic neurons stimulating inhibitory neuronal signals in post-synaptic neurons, has been around for over 5 decades. Baclofen is used primarily for spasticity and since 1982, has had a role as an intrathecal agent. In the present investigation, we review research trends and updates on safety and efficacy of intrathecal baclofen (ITB) pumps.
Evaluation of safety and efficacy of ITB pumps in spasticity and relevant conditions was evaluated in the present investigation. PubMed and ClinicalTrials.gov were used to review appropriate related literature. Commonly reported aspects regarding ITB efficacy include comparison with alternative treatments, maintenance efficacy, and long-term outcomes. Safety considerations and risk factors associated with ITB include postoperative complications, withdrawal symptoms, tolerance issues, long-term management, and contraindications. In summary, the present investigation reveals that ITB is efficacious for muscle spasticity; however, efforts should be made to enhance safety and efficacy by providing improved best practice guidelines on maximum safe dose with the least amount of risk with individualized treatments.
巴氯芬是一种肌肉松弛剂，可减少突触前神经元中兴奋性神经递质的释放，从而刺激突触后神经元中的抑制性神经信号，它已问世50多年。巴氯芬主要用于治疗痉挛，自1982年以来，一直作为鞘内给药药物。在本研究中，我们回顾了鞘内注射巴氯芬（ITB）泵安全性和有效性的研究趋势及最新进展。
本研究评估了ITB泵在痉挛及相关病症中的安全性和有效性。利用PubMed和ClinicalTrials.gov检索了相关文献。关于ITB疗效的常见报告内容包括与其他治疗方法的比较、维持疗效及长期预后。与ITB相关的安全考量和风险因素包括术后并发症、撤药症状、耐受性问题、长期管理及禁忌证。总之，本研究表明ITB对肌肉痉挛有效；然而，应通过提供关于最大安全剂量的改进最佳实践指南，以最小风险进行个体化治疗，来提高其安全性和有效性。
