疟疾单克隆抗体可阻断脑部结合。
Malaria monoclonals block brain binding.
作者信息
Rogerson Stephen J, Walker Isobel S, Aitken Elizabeth H
机构信息
Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.
Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.
出版信息
Trends Parasitol. 2025 Feb;41(2):78-79. doi: 10.1016/j.pt.2024.12.010. Epub 2025 Jan 3.
Abstract
In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs, including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected cells from binding to the endothelial protein C receptor (EPCR) in a model of brain blood vessels. EPCR-blocking monoclonals could form the basis of new treatments for severe malaria.
摘要
在恶性疟原虫疟疾中，受感染的细胞会在包括大脑在内的器官血管中积聚。最近，雷耶斯等人在脑血管理模型中鉴定出了能阻止受感染细胞与内皮蛋白C受体（EPCR）结合的单克隆抗体。阻断EPCR的单克隆抗体可能成为重症疟疾新疗法的基础。
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本文引用的文献
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Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1.内皮细胞蛋白C受体结合会诱导与重症疟疾相关的A组恶性疟原虫红细胞膜蛋白1（PfEMP1）发生构象变化。
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