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本文引用的文献

1
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Nature. 2024 Dec;636(8041):182-189. doi: 10.1038/s41586-024-08220-3. Epub 2024 Nov 20.
2
A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.一种系统血清学方法，用于鉴定马拉维儿童中抗大脑疟疾的关键抗体保护相关性。
BMC Med. 2024 Sep 12;22(1):388. doi: 10.1186/s12916-024-03604-8.
3
PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity.PfEMP1 和 var 基因——在恶性疟原虫致病机制和免疫中仍然具有关键重要性。
Adv Parasitol. 2024;125:53-103. doi: 10.1016/bs.apar.2024.02.001. Epub 2024 Mar 23.
4
Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria.皮下注射单克隆抗体预防疟疾。
N Engl J Med. 2024 May 2;390(17):1549-1559. doi: 10.1056/NEJMoa2312775. Epub 2024 Apr 26.
5
Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1.内皮细胞蛋白C受体结合会诱导与重症疟疾相关的A组恶性疟原虫红细胞膜蛋白1（PfEMP1）发生构象变化。
Structure. 2023 Oct 5;31(10):1174-1183.e4. doi: 10.1016/j.str.2023.07.011. Epub 2023 Aug 14.
6
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination.感染而非亚单位疫苗接种可诱导无岩藻糖基化恶性疟原虫特异性 IgG。
Nat Commun. 2021 Oct 5;12(1):5838. doi: 10.1038/s41467-021-26118-w.
7
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria.将 EPCR 结合 PfEMP1 与儿科疟疾的脑水肿联系起来。
Cell Host Microbe. 2017 Nov 8;22(5):601-614.e5. doi: 10.1016/j.chom.2017.09.009. Epub 2017 Oct 26.
8
Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria.恶性疟原虫EPCR结合型PfEMP1的表达随疟疾疾病严重程度增加而升高，且在无视网膜病变的脑型疟疾中升高。
BMC Med. 2017 Oct 13;15(1):183. doi: 10.1186/s12916-017-0945-y.
9
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.基于结构的与脑型疟疾相关的双受体结合型疟原虫红细胞膜蛋白1家族的鉴定
Cell Host Microbe. 2017 Mar 8;21(3):403-414. doi: 10.1016/j.chom.2017.02.009.
10
Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria.单纯性或重症疟疾患者抗体所识别的恶性疟原虫红细胞膜蛋白1（PfEMP1）的差异。
Malar J. 2016 May 5;15(1):258. doi: 10.1186/s12936-016-1296-4.

疟疾单克隆抗体可阻断脑部结合。

Malaria monoclonals block brain binding.

作者信息

Rogerson Stephen J, Walker Isobel S, Aitken Elizabeth H

机构信息

Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.

Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.

出版信息

Trends Parasitol. 2025 Feb;41(2):78-79. doi: 10.1016/j.pt.2024.12.010. Epub 2025 Jan 3.

DOI:10.1016/j.pt.2024.12.010
PMID:39755505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11802285/
Abstract

In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs, including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected cells from binding to the endothelial protein C receptor (EPCR) in a model of brain blood vessels. EPCR-blocking monoclonals could form the basis of new treatments for severe malaria.

摘要

在恶性疟原虫疟疾中，受感染的细胞会在包括大脑在内的器官血管中积聚。最近，雷耶斯等人在脑血管理模型中鉴定出了能阻止受感染细胞与内皮蛋白C受体（EPCR）结合的单克隆抗体。阻断EPCR的单克隆抗体可能成为重症疟疾新疗法的基础。