Chang Bo, Zhang Xiangfeng, Fang Riliang, Li Huibin, Zhou Youdan, Wang Yakun
Department of Cardiology, The Sixth People's Hospital of Nantong, Nantong, 226001, China.
Department of Internal Medicine, Shanghai Hospital of PAP, Shanghai, 201103, China.
J Cardiothorac Surg. 2025 Jan 4;20(1):12. doi: 10.1186/s13019-024-03258-w.
BACKGROUND & OBJECTIVE: Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. This study aimed to investigate the clinical significance of miR-30c-5p for ACS and to provide a convenient biomarker for diagnosing of ACS.
Baseline information was collected from a total of 173 subjects (98 ACS subjects and 65 healthy subjects). The miR-30c-5p expression was evaluated by the Polymerase chain reaction (PCR). The predictive value of miR-30c-5p for ACS was assessed by Receiver Operating Characteristic (ROC) curve and multivariate logistic regression analysis. The relationship between miR-30c-5p expression and ACS severity was assessed by correlation analysis. Furthermore, the prognostic value of miR-30c-5p on Major Adverse Cardiovascular Events (MACE) occurrence was assessed by the Kaplan-Meier (K-M) curve to evaluate its prognostic significance.
Downregulation of miR-30c-5p was observed in ACS subjects and its diagnostic value on ACS was confirmed by the ROC curve. MiR-30c-5p could also discriminate acute myocardial infarction (AMI) from unstable angina pectoris (UAP) subjects in ACS. The expression of miR-30c-5p was negatively correlated with the cardiac troponin I (cTnI) levels and the Gensini score. A lower miR-30c-5p expression was observed in ACS subjects who developed MACE (P = 0.020), and the K-M curve further confirmed the close correlation between miR-30c-5p expression and MACE occurrence in ACS. MiR-30c-5p was also identified as an independent prognostic factor for MACE in ACS.
Serum miR-30c-5p expression was correlated with the severity of ACS, and downregulated miR-30c-5p expression showed a diagnostic and prognostic value in ACS.
对急性冠状动脉综合征（ACS）进行及时干预可有效降低ACS患者的死亡率。本研究旨在探讨miR-30c-5p对ACS的临床意义，并为ACS的诊断提供一种便捷的生物标志物。
收集了总共173名受试者（98名ACS受试者和65名健康受试者）的基线信息。通过聚合酶链反应（PCR）评估miR-30c-5p的表达。通过受试者工作特征（ROC）曲线和多因素逻辑回归分析评估miR-30c-5p对ACS的预测价值。通过相关性分析评估miR-30c-5p表达与ACS严重程度之间的关系。此外，通过Kaplan-Meier（K-M）曲线评估miR-30c-5p对主要不良心血管事件（MACE）发生的预后价值，以评估其预后意义。
在ACS受试者中观察到miR-30c-5p表达下调，ROC曲线证实了其对ACS的诊断价值。miR-30c-5p还可区分ACS中的急性心肌梗死（AMI）和不稳定型心绞痛（UAP）受试者。miR-30c-5p的表达与心肌肌钙蛋白I（cTnI）水平和Gensini评分呈负相关。在发生MACE的ACS受试者中观察到较低的miR-30c-5p表达（P = 0.020），K-M曲线进一步证实了miR-30c-5p表达与ACS中MACE发生之间的密切相关性。miR-30c-5p也被确定为ACS中MACE的独立预后因素。
血清miR-30c-5p表达与ACS的严重程度相关，miR-30c-5p表达下调在ACS中具有诊断和预后价值。
