Barati Leila, Vakili Mohammadali, Mehrpour Omid, Teimoorian Mehrdad
Neonatal and Children's Health Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Health Management and Social Development Research Center, Department of Biostatistics and Epidemiology, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran.
Sci Rep. 2025 Jan 4;15(1):802. doi: 10.1038/s41598-024-79424-w.
Children are highly sensitive to toxins which can damage their organs and lead to death. Investigating the main causes of intoxication could reduce mortality and morbidity in children. In this cross-sectional study, the documents of all poisoned patients (214 cases) admitted to the emergency department of Taleghani children`s Hospital between April 2020 and 2023 were investigated. Approximately 51% of them were females. There were 87 cases (45.3%) of illicit drug poisoning, which included methadone 43.8%, opium 41.4%, amphetamine 8.2%, cannabis 3.3%, buprenorphine 2.2%, and tramadol 1.1%. Children who were poisoned by illicit drugs presented with impaired level of consciousness (92.5%), unstable vital signs and abnormal laboratory results. The level of serum glucose was higher in methadone toxicity. Three and two cases, due to methadone and opium poisoning died. Children with illicit drugs poisoning in terms of vital signs and laboratory data were worse compared to other poisonings and mortality is high in this group. In this study, the blood sugar in methadone poisoning cases was statistically significantly different from other drugs, and it is suggested that in cases of children suspected of poisoning with illicit drugs and high blood sugar, methadone poisoning should be considered in the differential diagnosis.
儿童对毒素高度敏感，毒素会损害他们的器官并导致死亡。调查中毒的主要原因可以降低儿童的死亡率和发病率。在这项横断面研究中，对2020年4月至2023年期间入住塔莱加尼儿童医院急诊科的所有中毒患者（214例）的病历进行了调查。其中约51%为女性。有87例（45.3%）非法药物中毒，其中美沙酮占43.8%，鸦片占41.4%，苯丙胺占8.2%，大麻占3.3%，丁丙诺啡占2.2%，曲马多占1.1%。非法药物中毒的儿童出现意识水平受损（92.5%）、生命体征不稳定和实验室检查结果异常。美沙酮中毒时血清葡萄糖水平较高。有3例因美沙酮中毒死亡，2例因鸦片中毒死亡。与其他中毒相比，非法药物中毒儿童在生命体征和实验室数据方面情况更差，该组死亡率较高。在本研究中，美沙酮中毒病例的血糖与其他药物在统计学上有显著差异，建议在疑似非法药物中毒且血糖高的儿童病例中，鉴别诊断时应考虑美沙酮中毒。
