Mehrnia Nariman, Jaliliyan Ali, Mosavari Hesam, Khalili Pantea, Heidari Fatemeh, Mohammadi Manizhe Amir, Teimoury Taher, Fakhri Elham, Moradi Mohammad, Hosseininasab Ali, Eghbali Foolad
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, School of Medicine, Rasool‑E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Obes Surg. 2025 Feb;35(2):505-513. doi: 10.1007/s11695-024-07570-1. Epub 2025 Jan 4.
Obesity, characterized by excessive adipose tissue, is associated with chronic low-grade inflammation and elevated inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP). This inflammation is linked to obesity-associated medical problems, including cardiovascular diseases. One anastomosis gastric bypass (OAGB) has emerged as an effective metabolic and bariatric surgical procedure to address severe obesity and its associated inflammatory state. This study aims to evaluate the changes in hs-CRP levels following OAGB in patients with obesity.
In this prospective cohort study, 71 participants with BMI > 35 kg/m, with or without obesity-associated medical problems, underwent OAGB. The hs-CRP levels were measured at baseline, 1 day, 5 days, 30 days, and 6 months post-surgery.
The median baseline hs-CRP level was 8.5 mg/L, initially increasing post-surgery to 19 mg/L, but significantly decreased to 3.5 mg/L at 6 months (p < 0.001). Significant reductions in weight and BMI were also observed, with median total weight loss (%TWL) of 29% and excess weight loss (%EWL) of 68.2% over 6 months. Pre-operative hs-CRP levels were the only significant predictor of CRP reduction post-surgery.
OAGB significantly reduces systemic inflammation by decreasing hs-CRP levels, alongside substantial weight loss. These findings support OAGB as a beneficial intervention for mitigating inflammation and improving metabolic conditions in patients with obesity. Further, long-term studies are warranted to evaluate the sustained impact of OAGB on inflammatory markers and obesity-associated medical problems.
肥胖以脂肪组织过多为特征，与慢性低度炎症及炎症标志物升高有关，如高敏C反应蛋白（hs-CRP）。这种炎症与肥胖相关的医学问题有关，包括心血管疾病。单吻合口胃旁路术（OAGB）已成为一种有效的代谢和减肥手术，用于治疗严重肥胖及其相关的炎症状态。本研究旨在评估肥胖患者接受OAGB术后hs-CRP水平的变化。
在这项前瞻性队列研究中，71名BMI>35kg/m²、有或无肥胖相关医学问题的参与者接受了OAGB手术。在基线、术后1天、5天、30天和6个月时测量hs-CRP水平。
hs-CRP的基线水平中位数为8.5mg/L，术后最初升至19mg/L，但在6个月时显著降至3.5mg/L（p<0.001）。体重和BMI也显著降低，6个月内总体重减轻中位数（%TWL）为29%，超重减轻中位数（%EWL）为68.2%。术前hs-CRP水平是术后CRP降低的唯一显著预测因素。
OAGB通过降低hs-CRP水平显著减轻全身炎症，同时大幅减轻体重。这些发现支持OAGB作为一种有益的干预措施，可减轻肥胖患者的炎症并改善代谢状况。此外，有必要进行长期研究以评估OAGB对炎症标志物和肥胖相关医学问题的持续影响。
