General Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Obes Surg. 2020 Jun;30(6):2338-2344. doi: 10.1007/s11695-020-04471-x.
One anastomosis gastric bypass (OAGB) is a promising bariatric procedure. We performed this study to evaluate the changes in a group of inflammatory cytokines 12 months after OAGB.
A single-arm prospective study was conducted on obese patients who underwent OAGB. The serum levels of the following adipocytokines were monitored pre- and 12 months postoperatively: adiponectin, leptin, interleukin 6 (IL-6), interleukin 8 (IL-8) levels, tumor necrosis factor-alpha (TNF-α), serum amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP), and monocyte chemotactic protein 1 (MCP-1).
A total of 62 patients were included with a mean age of 43.9 ± 6.8 years old. The serum adiponectin increased significantly from 7.64 ± 0.29 to 8.76 ± 0.42 μg/mL 12 months after the operation (p < 0.001). hs-CRP and IL-6 decreased significantly 12 months after the OAGB from 3323.35 ± 643.4 ng/mL and 3.72 ± 7.7 pg/mL to 1376.81 ± 609.4 ng/mL and 3.64 ± 6.9 pg/mL, respectively (p < 0.001). The MCP-1 showed significant increase in its level after OAGB as well (p = 0.014). In contrary, there were no significant changes in serum levels of IL-8 (p = 0.12) and TNF-α (p = 0.84) 12 months after the operation. The correlation analysis showed significant correlations between initial body mass index (BMI) with serum adiponectin, IL-8, and serum SAA.
OAGB can significantly impact the inflammatory cytokine profile in obese patients with possible subsequent protection from obesity-related comorbidities such as insulin resistance, cardiovascular diseases, and certain cancers.
单吻合口胃旁路术（OAGB）是一种有前途的减肥手术。我们进行这项研究是为了评估 OAGB 术后 12 个月一组炎症细胞因子的变化。
对接受 OAGB 的肥胖患者进行单臂前瞻性研究。监测术前和术后 12 个月以下脂肪细胞因子的血清水平：脂联素、瘦素、白细胞介素 6 (IL-6)、白细胞介素 8 (IL-8)、肿瘤坏死因子-α (TNF-α)、血清淀粉样蛋白 A (SAA)、高敏 C 反应蛋白 (hs-CRP)和单核细胞趋化蛋白 1 (MCP-1)。
共纳入 62 例患者，平均年龄 43.9±6.8 岁。术后 12 个月，血清脂联素从 7.64±0.29μg/mL 显著增加至 8.76±0.42μg/mL（p<0.001）。术后 12 个月，OAGB 后 hs-CRP 和 IL-6 分别从 3323.35±643.4ng/mL 和 3.72±7.7pg/mL 显著下降至 1376.81±609.4ng/mL 和 3.64±6.9pg/mL（p<0.001）。MCP-1 水平也显著升高（p=0.014）。相反，术后 12 个月血清 IL-8（p=0.12）和 TNF-α（p=0.84）水平无明显变化。相关性分析显示，初始体重指数（BMI）与血清脂联素、IL-8 和血清 SAA 呈显著相关。
OAGB 可显著影响肥胖患者的炎症细胞因子谱，可能随后对肥胖相关的合并症（如胰岛素抵抗、心血管疾病和某些癌症）产生保护作用。
