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腹腔干动脉支架置入术成功治愈难治性边缘溃疡。

Successful resolution of refractory marginal ulcer with celiac artery stenting.

作者信息

Elkhattib Ismail, Abdelwahed Ahmed H, Villavicencio Jaimy, Rezaizadeh Houman

机构信息

Hartford Healthcare, Connecticut, USA.

University of Connecticut, Connecticut, USA.

出版信息

Clin J Gastroenterol. 2025 Apr;18(2):288-292. doi: 10.1007/s12328-024-02091-x. Epub 2025 Jan 4.

DOI:10.1007/s12328-024-02091-x
PMID:39755828
Abstract

Marginal ulcers are a common complication following Roux-en-Y bypass surgeries with an approximate incidence of 4.6%. The pathophysiology is complex and risk factors include smoking, nonsteroidal anti-inflammatory drugs (NSAIDs) use, Helicobacter pylori infection, and a larger pouch size. The management is usually medical encompassing control of modifiable risk factors and the administration of acid-reducing medications with data pointing towards faster healing time by using open capsule proton pump inhibitors (PPIs). Emergent surgical management is indicated for complication such as fistula formation, perforation, stricture, or intractable bleeding. Multiple surgical approaches have been proposed in the past, including: resection of the gastrojejunal (GJ) junction, revision of the bypass and total gastrectomy for recurrent ulcers. We present a unique case of a complicated recurrent marginal ulcer after Roux-en-Y surgery in a patient with multiple surgical revisions that healed completely after placing a celiac artery stent for severe celiac artery stenosis. Our case highlights an association between ischemia and marginal ulcers. This association has been previously theorized, however, there is scarce evidence to support this theory. Our case not only supports this belief but also introduces a novel and potential alternative treatment for resistant marginal ulcers that have failed medical therapy. Our approach hypothesizes that addressing ischemia as the culprit for recurrent marginal ulcers in high-risk populations, might be a minimally invasive, yet successful method for treatment.

摘要

边缘性溃疡是Roux-en-Y胃旁路手术后常见的并发症,发生率约为4.6%。其病理生理过程复杂,危险因素包括吸烟、使用非甾体抗炎药(NSAIDs)、幽门螺杆菌感染以及胃囊较大。治疗通常采用药物治疗,包括控制可改变的危险因素和使用抑酸药物,有数据表明使用开放胶囊质子泵抑制剂(PPIs)可加快愈合时间。对于瘘管形成、穿孔、狭窄或顽固性出血等并发症,需进行紧急手术治疗。过去曾提出多种手术方法,包括:胃空肠(GJ)吻合口切除术、旁路手术修正术以及复发性溃疡的全胃切除术。我们报告了一例独特的病例,一名接受过多次手术修正的患者在Roux-en-Y手术后出现复杂的复发性边缘性溃疡,在因严重腹腔动脉狭窄置入腹腔动脉支架后完全愈合。我们的病例突出了缺血与边缘性溃疡之间的关联。这种关联此前已有理论推测,但缺乏支持该理论的证据。我们的病例不仅支持了这一观点,还为药物治疗无效的难治性边缘性溃疡引入了一种新颖且潜在的替代治疗方法。我们的方法假设,将缺血视为高危人群复发性边缘性溃疡的病因,可能是一种微创但成功的治疗方法。

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本文引用的文献

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Marginal Ulcers after Roux-en-Y Gastric Bypass: Etiology, Diagnosis, and Management.Roux-en-Y胃旁路术后边缘性溃疡:病因、诊断与治疗
J Clin Med. 2023 Jun 28;12(13):4336. doi: 10.3390/jcm12134336.
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