Piazza Cesare, Montenegro Claudia, Tomasoni Michele, Leivo Ilmo, Stenman Göran, Agaimy Abbas, Simpson Roderick H W, Zidar Nina, Ferlito Alfio
Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, School of Medicine, University of Brescia, Brescia, Italy.
Oncol Ther. 2025 Mar;13(1):49-67. doi: 10.1007/s40487-024-00323-1. Epub 2025 Jan 5.
Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes.
Papers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included.
A total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence.
Aggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion.
喉软骨肉瘤（CS）是一种罕见的惰性恶性肿瘤。高级别（G3）、去分化（DD）和黏液样（MY）CS因其转移潜能和相对较差的预后被认为是更具侵袭性的亚型。本系统评价的目的是评估受这些较罕见CS亚型影响的患者的治疗方式和生存结果。
纳入2000年1月1日至2024年8月25日发表的描述喉G3、DD和MY CS病例的论文。
共纳入38例患者（15例G3、13例DD和10例MY）。环状软骨是最常见的起源部位。常施行全喉切除术（TL）。42.8%的患者采用原发性保守治疗方法后出现局部区域复发。
与低级别CS相比，CS的侵袭性亚型由于局部区域和远处复发率较高，需要采取根治性方法。根治性全喉切除术是最常见的治疗方法，应在仔细的多学科讨论后考虑辅助治疗。
