Yilmaz Ugur, Rowe Steven P, Marks Lawrence B
Department of Radiation Oncology, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul 34865, Türkiye.
Department of Radiology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
J Clin Med. 2025 Apr 17;14(8):2762. doi: 10.3390/jcm14082762.
This study investigates the association between synchronous and metachronous metastases across various cancer types, evaluating whether that relationship has evolved over time. Data from the Surveillance, Epidemiology, and End Results (SEER)-8 dataset from 1975 to 2020 were retrospectively reviewed. For each of the 18 solid tumor types, the crude rates of synchronous and metachronous metastases were estimated from the SEER database. For each of the years assessed (from 1975 to 2015 at 10-year increments), linear regression analyses were conducted to quantify the relationship between the rates of metachronous metastasis and synchronous metastasis across all cancer sites. The of association over time were compared using a Fisher's z-transformation. At all time points considered, there was a significant association between the rates of metachronous and synchronous metastases (all values < 0.05 for 5-year follow-up data). The of that association tended to increase over time (R = 0.59, 0.60, 0.66, 0.80, and 0.87 for 1975, 1985, 1995, 2005, and 2015, respectively), with the value of the z-score comparing the many R values over time varying from 0.04 to 0.48. There appears to be an increasing association between the rates of synchronous and metachronous distant metastases over time. The exact cause of this increasing association is unknown. However, it appears to have occurred somewhat contemporaneous with the increasing use of more-accurate imaging studies (e.g., FDG-PET). Newer, targeted radiotracers for PET may provide the landscape for a prospective evaluation of the role of imaging.
本研究调查了不同癌症类型中同时性转移和异时性转移之间的关联，评估这种关系是否随时间演变。对1975年至2020年监测、流行病学和最终结果（SEER）-8数据集的数据进行了回顾性分析。对于18种实体瘤类型中的每一种，从SEER数据库中估计同时性转移和异时性转移的粗发病率。对于评估的每一年（从1975年到2015年，以10年为增量），进行线性回归分析，以量化所有癌症部位异时性转移率和同时性转移率之间的关系。使用Fisher z变换比较随时间的关联度。在所有考虑的时间点，异时性转移率和同时性转移率之间存在显著关联（5年随访数据的所有P值<0.05）。这种关联度随时间趋于增加（1975年、1985年、1995年、2005年和2015年的R值分别为0.59、0.60、0.66、0.80和0.87），比较不同时间多个R值的z分数的P值在0.04至0.48之间变化。随着时间的推移，同时性和异时性远处转移率之间的关联似乎在增加。这种关联增加的确切原因尚不清楚。然而，它似乎与更精确成像研究（如FDG-PET）使用的增加在一定程度上同时发生。新型的PET靶向放射性示踪剂可能为前瞻性评估成像的作用提供条件。
