文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

m6A RNA修饰途径：协调多个器官的纤维化机制

m6A RNA modification pathway: orchestrating fibrotic mechanisms across multiple organs.

作者信息

Huang Xiangfei, Yu Zilu, Tian Juan, Chen Tao, Wei Aiping, Mei Chao, Chen Shibiao, Li Yong

机构信息

Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Donghu District, Nanchang 330006, China.

Queen Mary School, Medical College, Nanchang University, 1299 Xuefu Road, Honggutan District, Nanchang 330031, China.

出版信息

Brief Funct Genomics. 2025 Jan 15;24. doi: 10.1093/bfgp/elae051.

DOI:10.1093/bfgp/elae051
PMID:39756462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11735750/
Abstract

Organ fibrosis, a common consequence of chronic tissue injury, presents a significant health challenge. Recent research has revealed the regulatory role of N6-methyladenosine (m6A) RNA modification in fibrosis of various organs, including the lung, liver, kidney, and heart. In this comprehensive review, we summarize the latest findings on the mechanisms and functions of m6A modification in organ fibrosis. By highlighting the potential of m6A modification as a therapeutic target, our goal is to encourage further research in this emerging field and support advancements in the clinical treatment of organ fibrosis.

摘要

器官纤维化是慢性组织损伤的常见后果，对健康构成重大挑战。最近的研究揭示了N6-甲基腺苷（m6A）RNA修饰在包括肺、肝、肾和心脏在内的各种器官纤维化中的调节作用。在这篇综述中，我们总结了m6A修饰在器官纤维化中的机制和功能的最新发现。通过强调m6A修饰作为治疗靶点的潜力，我们的目标是鼓励在这个新兴领域进行进一步研究，并支持器官纤维化临床治疗的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0441/11735750/74f15a6a2d08/elae051f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0441/11735750/b6754349d20d/elae051f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0441/11735750/74f15a6a2d08/elae051f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0441/11735750/b6754349d20d/elae051f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0441/11735750/74f15a6a2d08/elae051f2.jpg

相似文献

[1]
m6A RNA modification pathway: orchestrating fibrotic mechanisms across multiple organs.

Brief Funct Genomics. 2025-1-15

[2]
N6-methyladenosine RNA modification: A promising regulator in central nervous system injury.

Exp Neurol. 2021-11

[3]
N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases.

Clin Epigenetics. 2024-9-12

[4]
Functions of RNA N6-methyladenosine modification in cancer progression.

Mol Biol Rep. 2019-4

[5]
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect.

Biochem Pharmacol. 2023-12

[6]
Role of m6A RNA Methylation in Ischemic Stroke.

Mol Neurobiol. 2024-9

[7]
N6-methyladenosine–encoded epitranscriptomics.

Nat Struct Mol Biol. 2016-2

[8]
Functions of N6-methyladenosine (m6A) RNA modifications in acute myeloid leukemia.

J Leukoc Biol. 2024-10-1

[9]
m6A epitranscriptomic and epigenetic crosstalk in liver fibrosis: Special emphasis on DNA methylation and non-coding RNAs.

Cell Signal. 2024-10

[10]
RNA methylation and breast cancer: insights into m6A, m7G and m5C.

Mol Biol Rep. 2024-11-29

引用本文的文献

[1]
Bidirectional Role of Pericytes in Ischemic Stroke.

Brain Sci. 2025-6-4

本文引用的文献

[1]
Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer.

J Nanobiotechnology. 2024-6-19

[2]
ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.

Nat Commun. 2024-3-5

[3]
Targeting the mA RNA methyltransferase METTL3 attenuates the development of kidney fibrosis.

Exp Mol Med. 2024-2

[4]
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

EMBO J. 2024-1

[5]
TNC Accelerates Hypoxia-Induced Cardiac Injury in a METTL3-Dependent Manner.

Genes (Basel). 2023-2-26

[6]
METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition.

J Mol Cell Biol. 2023-8-3

[7]
N-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.

Ecotoxicol Environ Saf. 2023-4-1

[8]
Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment.

Nat Commun. 2023-3-1

[9]
DNA 5mC and RNA mA modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression.

Cell Death Differ. 2023-5

[10]
mA methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.

Pharmacol Res. 2023-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索