Huang Xiangfei, Yu Zilu, Tian Juan, Chen Tao, Wei Aiping, Mei Chao, Chen Shibiao, Li Yong
Department of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Donghu District, Nanchang 330006, China.
Queen Mary School, Medical College, Nanchang University, 1299 Xuefu Road, Honggutan District, Nanchang 330031, China.
Brief Funct Genomics. 2025 Jan 15;24. doi: 10.1093/bfgp/elae051.
Organ fibrosis, a common consequence of chronic tissue injury, presents a significant health challenge. Recent research has revealed the regulatory role of N6-methyladenosine (m6A) RNA modification in fibrosis of various organs, including the lung, liver, kidney, and heart. In this comprehensive review, we summarize the latest findings on the mechanisms and functions of m6A modification in organ fibrosis. By highlighting the potential of m6A modification as a therapeutic target, our goal is to encourage further research in this emerging field and support advancements in the clinical treatment of organ fibrosis.
器官纤维化是慢性组织损伤的常见后果，对健康构成重大挑战。最近的研究揭示了N6-甲基腺苷（m6A）RNA修饰在包括肺、肝、肾和心脏在内的各种器官纤维化中的调节作用。在这篇综述中，我们总结了m6A修饰在器官纤维化中的机制和功能的最新发现。通过强调m6A修饰作为治疗靶点的潜力，我们的目标是鼓励在这个新兴领域进行进一步研究，并支持器官纤维化临床治疗的进展。
