N6-甲基腺苷修饰的转录组学。
N6-methyladenosine–encoded epitranscriptomics.
出版信息
Nat Struct Mol Biol. 2016 Feb;23(2):98-102. doi: 10.1038/nsmb.3162.
PMID:26840897
Abstract
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m6A modification, which affects many different stages of the RNA life cycle.
摘要
N6-甲基腺嘌呤（m6A）是真核 mRNA 中最丰富的内部修饰。m6A 位置、功能和机制的最新发现揭示了 RNA 水平上基因调控的一个新层次，从而产生了 m6A 转录后修饰组学领域。在本观点中，我们提供了哺乳动物 m6A 修饰的各种影响的最新更新，这些影响涉及 RNA 生命周期的许多不同阶段。
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