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N6-甲基腺苷修饰的转录组学。

N6-methyladenosine–encoded epitranscriptomics.

出版信息

Nat Struct Mol Biol. 2016 Feb;23(2):98-102. doi: 10.1038/nsmb.3162.

DOI:10.1038/nsmb.3162
PMID:26840897
Abstract

N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m6A modification, which affects many different stages of the RNA life cycle.

摘要

N6-甲基腺嘌呤（m6A）是真核 mRNA 中最丰富的内部修饰。m6A 位置、功能和机制的最新发现揭示了 RNA 水平上基因调控的一个新层次，从而产生了 m6A 转录后修饰组学领域。在本观点中，我们提供了哺乳动物 m6A 修饰的各种影响的最新更新，这些影响涉及 RNA 生命周期的许多不同阶段。

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N6-Methyladenosine Modification of the Three Components "Writers", "Erasers", and "Readers" in Relation to Osteogenesis.

Int J Mol Sci. 2025-6-12

[2]
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[3]
Integration of bioinformatics and identification of the role of m6A genes in NAFLD.

PLoS One. 2025-5-28

[4]
Epitranscriptomic Role of m6A in Obesity-Associated Disorders and Cancer Metabolic Reprogramming.

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[5]
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[6]
RNA modifications and their role in gene expression.

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[7]
m6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapy.

J Transl Med. 2025-2-28

[8]
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner.

Mol Med. 2025-2-25

[9]
TDP-43/ALKBH5-mediated mA modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition.

MedComm (2020). 2025-2-18

[10]
The Mechanism and Latest Progress of m6A Methylation in the Progression of Pancreatic Cancer.

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本文引用的文献

[1]
N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics.

Nat Struct Mol Biol. 2016-2

[2]
5' UTR m(6)A Promotes Cap-Independent Translation.

Cell. 2015-11-5

[3]
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

Nature. 2015-10-22

[4]
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Genes Dev. 2015-10-1

[5]
N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding.

J Mol Biol. 2016-2-27

[6]
HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.

Cell. 2015-9-10

[7]
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.

Genes Dev. 2015-7-1

[8]
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Nat Methods. 2015-8

[9]
N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Cell. 2015-6-4

[10]
N6-methyladenosine marks primary microRNAs for processing.

Nature. 2015-3-26

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