Hajipour Somayeh, Ghiasvand Alireza
Lorestan Petrochemical Company, Central Laboratory.
Lorestan University, Chemistry.
Pharm Nanotechnol. 2024 Dec 30. doi: 10.2174/0122117385340986241208123048.
The drug was initially administrated relying on pills, eye drops, ointments, and intravenous solutions. In the last decades, several novel technologies have emerged to overcome significant challenges including poor solubility, drug aggregation, low bioavailability, limited biodistribution, poor absorption in the body, lack of selectivity, or to minimize the adverse effects of therapeutic drugs. Drug delivery systems (DDS) can be designed to the technologies that carry drugs into or throughout the body of humans or animals to enhance therapeutic efficacy. DDS can also be considered for in vivo delivery, particularly for their use in peptide and protein therapeutics. Continued research may show the trends and perspectives of how drugs are delivered. In addition, this article includes comprehensive information regarding the trends and perspectives in DDS technologies.
该药物最初通过药丸、眼药水、药膏和静脉注射液给药。在过去几十年中，出现了几种新技术来克服重大挑战，包括溶解度差、药物聚集、生物利用度低、生物分布有限、体内吸收差、缺乏选择性，或尽量减少治疗药物的不良反应。药物递送系统（DDS）可以设计成将药物输送到人体或动物体内或全身以提高治疗效果的技术。DDS也可考虑用于体内递送，特别是用于肽和蛋白质治疗。持续的研究可能会揭示药物递送的趋势和前景。此外，本文包含了有关DDS技术趋势和前景的全面信息。
