School of Biomedical Science and Engineering, South China University of Technology, Guangzhou 511442, China.
College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.
Molecules. 2024 Oct 13;29(20):4854. doi: 10.3390/molecules29204854.
Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption and inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through the use of nanomaterials and magnetic nanoparticles, offers innovative solutions to enhance drug solubility and bioavailability. This comprehensive review focuses on recent advancements and approaches in nanotechnology. We highlight both the successes and remaining challenges in this field, emphasizing the role of continued innovation. Future research should prioritize developing universal therapeutic solutions, conducting interdisciplinary research, and leveraging personalized nanomedicine to address biological variability.
生物变异性给有效的治疗方法的发展带来了重大挑战,特别是在药物溶解度和生物利用度方面。在不同的生理条件下溶解度差往往会导致吸收减少和治疗效果不一致。本综述探讨了纳米技术,特别是通过使用纳米材料和磁性纳米粒子,如何为提高药物溶解度和生物利用度提供创新解决方案。本综述重点介绍了纳米技术的最新进展和方法。我们强调了该领域的成功和仍然存在的挑战,强调了持续创新的作用。未来的研究应优先开发通用的治疗解决方案,开展跨学科研究,并利用个性化纳米医学来解决生物变异性。