Zhang Rui, Li Xintong, Liu Kemeng, Yang Meng, Dong Peiliang, Han Hua
College of Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Curr Protein Pept Sci. 2025;26(5):334-351. doi: 10.2174/0113892037335945241029111720.
Stroke is an acute cerebrovascular disease that causes brain tissue damage due to sudden blockage or rupture of blood vessels in the brain. According to the latest data from the Global Burden of Disease Study, the number of stroke patients worldwide is estimated to exceed 100 million, and more than 80% of patients suffer from stroke. Ischemic stroke is a type of stroke due to which two-thirds of the patients are disabled or even die, seriously affecting the patient's quality of life. Lactate is an indispensable substance in various physiological and pathological cells and plays a regulatory role in different aspects of energy metabolism and signal transduction. Studies have found that during cerebral ischemia and hypoxia, lactate concentration increases significantly, improving the energy supply to the ischemic area. Based on the scientific concept of lactate travelling through the brain, this article focuses on the important role of lactate as an energy source after ischemic stroke and analyzes the relationship between lactate as a signaling molecule and neuroprotection, angiogenesis, and anti-inflammatory effects. The aim of this study is to outline the molecular mechanisms by which lactate exerts its different effects in ischemic stroke. Some references are provided in this study for the research on lactate therapy for ischemic stroke.
中风是一种急性脑血管疾病，由于脑部血管突然堵塞或破裂而导致脑组织损伤。根据全球疾病负担研究的最新数据，全球中风患者数量估计超过1亿，其中超过80%的患者患有中风。缺血性中风是中风的一种类型，三分之二的患者因此致残甚至死亡，严重影响患者的生活质量。乳酸是各种生理和病理细胞中不可或缺的物质，在能量代谢和信号转导的不同方面发挥调节作用。研究发现，在脑缺血缺氧期间，乳酸浓度显著增加，改善了缺血区域的能量供应。基于乳酸在脑内转运的科学概念，本文重点阐述乳酸作为缺血性中风后能量来源的重要作用，并分析乳酸作为信号分子与神经保护、血管生成和抗炎作用之间的关系。本研究的目的是概述乳酸在缺血性中风中发挥不同作用的分子机制。本研究为缺血性中风乳酸治疗的研究提供了一些参考文献。
